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In Chapter V, as the finial chapter, we study conformational transition pathway of CaM.

第五章用靶向分子动力学研究了钙调蛋白的构象变化路径。

Denaturation with guanidine hydrochloride or urea is one of the primary ways of measuring the conformational stability of proteins and comparing the stability of mutant proteins.

测定天然蛋白质和蛋白质突变体构象稳定性的一个基本方法是在盐酸胍或脲作用下进行蛋白质变性研究。

Accordingly, in order to provide insight into the function of coenzyme B12 and the mechanism of enzymatic catalysis, it is necessary to investigate the conformational change of corrin ring accompa-nying the Co-C bond homolysis, the Co-C bond dissociation energy, and the factors influencing the Co-C bond strength.

激光诱导时间分辨光声量热法(laser-induced optoacoustic calorimetry，简称LIOAC；或time-resolved photoacoustic calorimetry，简称PAC)是在纳秒至微秒时间量级上直接定量检测激光诱导光化学反应及光生化反应过程中能量传递以及有关反应分子体积变化的新方法。

It shows that the cone conformation of the hosts is more stable than others when it is nottaking account of the solvent. Then, the possibility of the conformational interconversion of hosts at the different temperature iscalculated by molecular dynamics.

二是应用分子动力学方法探讨了在不同温度下各种构象之间相互转换的可能性，表明了当分子的下缘取代基团比较大时，增大了苯酚环发生翻转的空间位阻，各种构象之间翻转的难度将有所增加。

We explain the reason of conformational dependence of vertical ionization energy.

我们解释了天冬氨酸垂直电离能产生构型依赖性的原因。

Two anti-chicken, duck respiratory IgY (ND ++ Mycoplasma avian flu) and pathogens have unity, Conformational changes in the bacteria surface membrane electric field and launched lobulation of pathogenic cells and macrophage phagocytosis. the same time, pathogens in the body tissue adhesion, it is difficult to create lesions.

抗鸡、鸭呼吸道卵黄免疫球蛋白 IgY （禽流感+新城疫+支原体）与致病菌抱结后，改变了致病菌表面构象和细胞膜电场，发动分叶细胞和吞噬细胞对致病菌进行吞噬，同时组织致病菌黏附于肌体组织细胞，使其难以形成病灶。

Formation of micelle was in favor of DNA conformational compression and Zeta potential increase.

而这一过程形成的表面活性剂/DNA复合物可以作为潜在的非病毒基因载体。

All these results further demonstrate that the sequence 113-120 could play an important role in the conformational change of Prion proteins.

这些结果进一步证明，113-120序列在Prion蛋白构象变化中可能起着重要作用。

These alterations are related to a conformational change of the enzyme resulted from proteolysis.

这些变化与被修饰的酶出现的构象改变有关。

Currently activities involve (1) Investigation of dye-DNA interaction by using spectroscopic methods to probe the binding sites between chromophore and DNA and to identify various DNA conformational structures, particularly the telomeric DNA;(2) Investigation of the structure-activity correlation of anti-telomerase agents;(3) Design and synthesis new compounds for antitumor agents and fluorescence biomarkers;(4) Monitoring the folding and unfolding of quadruplex structure, tracing the pathway of drug delivery and probing drug-target interaction by using single molecule microscopy and spectroscopy.

目前 的研究重点分别是(1)利用光谱方法探讨探针分子与DNA的交互作用，特别是作用位置与结构变化；(2)研究抗端粒酵素作用分子之结构与生物活性之关系；(3)设计及合成抗肿瘤药剂或萤光生物标记；(4)建立单分子萤光光谱与影像技术，研究 DNA的多变型结构之变化机制，监测药物输送的路径过程及其在细胞中与标的物的作用。

This matter overthrew all basises I learned from Sunday school .

这件事把我从周日学校学到的所有道理都颠覆了。

It's one of the cruel ironies of aging: if you want to remember your favorite restaurants, the less you should eat at them.

这是一个老化的残酷讽刺：如果你想记住你最喜欢的餐馆，你应该更少吃到它们。