查询词典 breast cancer

Methods :A retrospectively analysis of pirh 2 mRNA expression in 87 cases of stage I and II breast cancer, 27 cases of stage III and IV breast cancer was made, and 10 cases of fibroma tissue and 6 cases of normal lacteal gland tissue as control, all of which were from Department of Breast Surgery, XiangYa Hospital in recent 10 years.

回顾性分析湘雅医院乳腺科近10年间收治的乳腺肿瘤患者的临床资料，其中包括I，II期乳腺癌87例，III，IV期乳腺癌27例Pirh2mRNA的表达，并以纤维瘤组织10例和正常乳腺组织6例作为对照。

Results of the 45 cases,3 cases were diagnosed as breast cancer (66.7% of them acted in accord with the pathological diagnose),10 papilloma (90%),6 papillomatosis (83.3%),21 mammary duct ectasia (90.5%),5 inflammatory disease of mammary (80%) Conclusion Breast fiberoptic ductoscopy can confirm etiological factors and locate the site of nipple discharge,and is effect in diagnosis of early breast cancer.

乳管镜能够更准确、直观明确乳头溢液性乳腺疾病的病因、病变范围及部位，是术前诊断以乳头溢液为表现的乳腺导管内乳头状瘤和导管内癌的有效手段。

METHODS: expression of Pgp and MDR1 mRNA were detected by immunohistochemistry and reverse transcriptionpolymerase chain reaction in the specimens from 25 breast cancer patients with neoadjuvant chemotherapy, 15 breast cancer patients without neoadjuvant chemotherapy and 10 patients with breast adenosis.

采用免疫组织化学及逆转录多聚酶链反应技术，对25例接受术前新辅助化疗的乳腺癌患者、15例未接受术前化疗的乳腺癌患者、10例乳腺腺病患者组织标本内Pgp 和MDR1 mRNA的表达情况进行检测。

METHODS: The expression of Pgp and MDR1 mRNA were detected by immunohistochemistry and reverse transcriptionpolymerase chain reaction in the specimens from 25 breast cancer patients with neoadjuvant chemotherapy, 15 breast cancer patients without neoadjuvant chemotherapy and 10 patients with breast adenosis.

采用免疫组织化学及逆转录多聚酶链反应技术，对25例接受术前新辅助化疗的乳腺癌患者、15例未接受术前化疗的乳腺癌患者、10例乳腺腺病患者组织标本内Pgp 和MDR1 mRNA的表达情况进行检测。

Results: 1 The incidence rate of primary bilateral breast cancers was 2.5％ with the morbidity age of 41 years, intermitting time between the two malignancies was 5.4 years. The 5－,10－ and 20－ year survival rates were 86.6％, 57.7％ and 25.8％ respectively. 2 The incidence rate of Paget′ s disease associated with breast cancer was 0.9％ with a high incident age of 47.3 years and 5－, 10－ and 20－ year survival rates of 64.7％, 50％ and 20.6％ respectively. 3 The incidence rate of breast cancer associated with MPMNs of other organs was 3.6％ with the peak incident age of 49.4 years, intermitting time of 8.6 years and the organs commonly involved were lung, uterus, esophagus, ovary and large intestine.

结果 ：1双原发乳腺癌发生率为2.5％，发病年龄41岁，间隔时间5.4年。5、10、20年生存率分别为86.6％、57.7％和25.8％。2同一乳腺PD伴乳腺癌发病率为0.9％，高发年龄为 47.3岁。5、10、20年生存率为：64.7％、50％和20.6％。3乳腺癌伴其他脏器癌瘤的MPMNs发生率为3.6％，高发年龄 49.4岁，间隔时间为8.6年。

The risk factors of breast carcinoma includes family history (The likelihood of developing breast cancer for a patient, if one of whose mother or sisters does, will increase by 1.5 to 3 times.), age, BMI, hereditary factors (The risk of developing breast cancer for a female whose BRCA1 gene has been mutated reaches 50-85% in her life.), female, contact history of the endogenous and exogenous estrogen, past history of chest being exposed to the radiation, dietary pattern, benign mastopathy and environmental factors.

发生乳腺肿瘤的危险因素包括：家族史（假如患者母亲或姐妹当中有一人发生乳腺癌，该患者乳腺癌发生的可能性增加1.5至3倍），年龄，肥胖，遗传性素因（BRCA1基因突变的女性一生中发生乳腺癌的可能性为50－85％），女性性别，内源性和外源性雌性激素接触，既往有过胸部放射性暴露史，膳食结构，良性乳腺疾病和环境因素。

Major pathological changes are duct ectasia and obvious periductal inflammatory changes.The clinical manifestations of PCM are breast mass and inflammatory changes,which should to be distinguished with advanced breast cancer and inflammatory breast cancer.

结果：乳腺导管扩张症临床表现为乳头溢液和乳腺肿物，主要与乳腺肿物和早期乳腺癌鉴别诊断，手术以局部切除多见，病理表现为导管扩张及导管周围明显炎性改变。

Methods:The changes of serum CYFRA21-1 level were detected by RIA method in 34 patients with breast benign diseases,47 patients with protopathic breast cancer before and after their operations and 56 patients with breast cancer only after operations.

采用放免法测定 34例乳腺良性疾病患者术前、47例乳腺癌患者术前和术后 4周及 56例乳腺癌术后随访患者的血清 CYFRA21-1 水平，进行对照分析。

Methods:The changes of serum CYFRA21-1 level were detected by RIA method in 34 patients with breast benign diseasesˇ47 patients with protopathic breast cancer before and after their operations and 56 patients with breast cancer only after operations.

方法ˇ采用放免法测定 34例乳ˇ良性疾病患者术前、47例乳ˇ癌患者术前和术后 4周及 56例乳ˇ癌术后随访患者的血清 CYFRA21-1 水平ˇ进行对照分析。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

We will see more and more activist government policies that distinguish economic activities according to the nationality of the actors.

我们将看到越来越多激进的政府政策，这些政策根据企业的国籍来区分经济活动。

If we can prove the independence of an axiomatic system, then we can guarantee the conciseness of this system, ie.

如果能够证明某个一阶谓词系统的独立性，那么就能够保证该系统的建立是精炼的，即没有任何一条公理或推理规则是多余的。