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The regulation of gene expression is to have relations to the assembly of the DNA binding proteins which bind to DNA to initiate the transcription. Some of these proteins have the ability to promote bending or looping of DNA. The FIS protein regulates gene expression in Escherichia coli by this property of bending DNA. There are many researches to discover the mechanism of FIS protein binds to DNA. However the experiment data only show the supposititious results and figure out the model of FIS-DNA complex structure. This research uses molecular dynamics simulation to compute the detail of the interaction between FIS and DNA. We observed FIS prominently affects the DNA bending by the type of local bending. Analyzing the DNA structure properties, roll and slide, also demonstrates the local bending type and region. The hydrogen bonds between FIS and DNA are analyzed to compare with the experiment data. Finally we compute the binding free energy between FIS and DNA to estimate the result of simulation and compare with the value of λ-repressor-DNA complex.

基因的表现与结合於DNA促使DNA转录作用起始的DNA结合蛋白组装有关，一些这类的蛋白质具有促使DNA扭曲或将DNA形成环状的能力，FIS蛋白质即是藉由扭曲DNA的特性调控大肠杆菌基因的表现，目前已有很多的研究发现FIS与DNA结合的机转，然而这些实验的数据仅能显示推测性的结果，进而利用这些结果推论出FIS与DNA聚合体结构的模型，本研究利用分子动态模拟的方式计算FIS与DNA交互作用的细节，我们观察到FIS主要影响DNA的扭曲方式为DNA区域扭曲的类型，并且分析DNA结构特性roll与slide也指出扭曲方式为区域扭曲与其扭曲的区域，我们也分析FIS与DNA之间的氢键，并且与实验的资料作比较，最后我们计算FIS与DNA之间的结合自由能评估模拟的结果，并且计算出的值和λ-repressor与DNA聚合体结构的实验值作比较。

In the part of empirical analysis of Chinese IPO first-day return, the difference between existing study and this study is that we use principal components analysis to extract from five factors to construct investors'sentiment index, add it to controled varibles, on which we examine the influence of offering mechanism on IPO first-day return. Moreover, we gather statistics and compare the IPO holding return for lockup period between fixed-price-class offering method and bookbuilding-class offering method, as well as price range between Chinese A-share market and Hongkong stock market, which prvide comprehensive evidence to appraise Chinese IPO bookbuilding mechanism. 2. Compare to the existing literatures which consider discount or allocation, incentive allocation and discount are considered at the same time in optimal mechanism design in this dissertation, and the offering bottom price is introduced to the price range. We investigate the relationship between price range and allocation quantity, and obtain the optimal price range and allocation strategy so that the advantages of independent allocation are reflected. On the other hand, the disadvantages of independent allocation are reflected in the manipulation in case of no restriction on IPO allocation. To distinguish from the existing literatures, bookbuilding mechanism is introduced to the model. We study the allocation strategy adopted by the underwriter in the pooling equilibrium of manipulation. In addition, we analyze the incentive compatibility conditions to which the existence of pooling equilibrium should satisfy and examine some factors'impact on the existence of manipulation.3. In bookbuilding without independent IPO allocation, Chinese realistic IPO background is considered and the condition of bookbuilding and fixed-price hybrid offering is added. Divide bookbuilding and fixed-price hybrid offering into sequential hybrid and simultaneous hybrid, and point out that the key points of subscription strategy in the two kinds of hybrid are different. Through modeling and simulation we obtain the impact of institutional investors'subscription strategy on bookbuilding without independent IPO allocation, which fill the gap in related research. Moreover, in the part of IPO bookbuilding with over-allotment option, the pricing strategy is divided into hot-IPO strategy and weak-IPO strategy. Take into account the procedure of Chinese IPO with over-allotment option, it presents how the underwriter determines the pricing strategy and what effect it brings to offering price and issue size through modeling and simulation. Therefore, it is instructive as a complement to existing literatures.

此外，对我国A股市场询价发行方式与固定价格发行方式下的IPO锁定期到期时持有收益率、以及我国A股市场与香港市场的询价发行价格区间进行了统计比较，为评价我国IPO市场的询价发行提供了比较全面的依据。2、相比已有文献仅考虑折价和分配中的一种激励措施，本论文在有自主配售权下的机制设计中并用了分配与折价两种激励措施，并且在价格区间的制定中引入发行底价，考察了价格区间与分配量之间的关系，得到最优的价格区间和分配策略，从中体现自主分配权的优点；在有自主分配权下的操纵行为研究中则体现了自主配售权的弊端，与已有文献不同的是，在模型中引入了累计投标询价机制，研究了承销商在混同均衡操纵中采取的分配策略，并对操纵存在的条件进行分析讨论，得出各个因素对混同均衡操纵存在的影响。3、在无自主分配权下的询价发行中，充分考虑了我国实际应用的背景，加入了与固定价格发售混合的条件，并将询价与固定价格混合发行分为序贯与同步两种方式，指出机构投资者在两种情况下申购策略的侧重点各有不同，通过对序贯混合发行方式下的网下累计投标策略以及同步混合发行方式下的资金分配策略的模型建立和数值仿真，考察了机构投资者申购策略对无自主分配权下的询价发行的影响，填补了相关研究文献的空白；在包含超额配售选择权的询价发行中，将发行定价策略分为热销策略和弱销策略，在考虑了我国含超额配售选择权的发行流程下，通过建模以及数值仿真得出承销商会对发行定价策略作出怎样的选取，进而会对新股发行价格、发售数量产生怎样的影响，对目前相关研究的缺乏做出了有益的补充。

In order to compare the theoretical price and real price of the warrants, this paper use control variate method to compare the GARCH Model and BS Model. The theoretical price of BS Model is used as control variate call option.

欲比较所模拟的权证理论价格及权证实际的价格，本文加入了控制变异法来进行模型的比较，以Black-Scholes模型的模拟价格当作控制变异买权，然后模拟出控制变异法的理论价格。

These problems of above just are in a few in small and slant of the decrescent on the website of little weight a few more apparent, compare tall website to weight or have a lot of advantages, no matter core keyword or special subject page compare stability.

以上的这些问题只是在一些中小并且偏小权重的网站上变小的比较明显一些，对于权重比较高的网站还是有很多优势，无论核心关键词还是专题页面都比较稳定。

Methods Carry out mfVEP detection to 30 AION (30 eyes) analysis second order kernel .The reaction was divided to dimidiate and quartered field .Analysis the sum totol waves of every reaction ,to compare every sector ,primary compare the waveshape characreristic with AION eyes and fellow eyes or treatment circa of AION eye.

对30例AION患者(30只眼)进行多焦VEP检测，主要分析mfVEP的二阶反应，将反应分上、下半侧视野，1/4象限视野(鼻上、鼻下、颞上、颞下)，分析各反应总和波，对各区域进行比较，主要比较AION眼与对侧眼及AION眼治疗前后各部分的波形特征。

OBJECTIVE: To compare the modeling process between open osteotomy model and closed fracture model in rats, and to compare fracture healing using radiograph.

目的：比较大鼠股骨开放截骨模型与闭合骨折模型的制作过程，并通过X射线摄片比较二者的骨折愈合情况。

Objective To establish rat model with polycystic ovary with two different methods:testosterone plus human chorionic gonadotropin and progestogen plus HCG,compare the rat models induced by testosterone plus HCG with the patients with polycystic ovary syndrome in the aspects of ovarial morphous and gonadal hormone,and investigate whether testosterone with HCG is the effective method to establish rat model with polycystic ovary syndrome,than compare two methods(T+HCG and P+HCG)finally to draw a conclusion if there are any difference or similary between the two methods and which one is more ideal and convenient.Methods 60 SD female rats of 23 days were divided into three groups in random.

目的 本实验用睾酮联合绒毛膜促性腺激素及炔诺孕酮联合HCG两种方法分别建立多囊卵巢大鼠模型，将模型鼠的卵巢形态及血清激素方面改变与人类多囊卵巢综合征的病理改变加以比较，探讨睾酮联合HCG是否是建立多囊卵巢大鼠模型的有效方法，并比较两种造模法是否存在异同点，判断哪一种造模方法更为理想及简便有效。

My thesis is divided into three chapters: In the first chapter, I mainly present the excavations of Oxyrhynchus, the discovery of the Hellenica Oxyrhynchia, the author, the organization, the style and the vocabulary of the Hellenica Oxyrhynchia as well as the time of writing and the scope of the content.In the second chapter, I mainly analyze the war at Ephesus, Megara and Notium recorded in the Cairo Fragment and Florence Fragment and compare them with other historian\'s records.In the third chapter, I analyze the contents of London Fragment item by item and compare the parallel records with the other historian\'s. I mainly discuss the prosperity of Thebes and the fall of Athens in the Peloponnesian War, the constitution of Boeotia, the recovery of Athens after the Peloponnesian War, the consolidation of Spartan hegemony, the Corinthian War, the democratic revolution of Rhodes, the relationship between Persia and the Greek City States, the political conflict inside the Greek City States, etc.

本文共分为三章：在第一章中，笔者主要探讨了奥克西林库斯的考古发掘、《奥克西林库斯希腊志》的发掘出土及其作者、体例、语言和风格、创作时间以及记载的内容；在第二章中，主要对《奥克西林库斯希腊志》的开罗断片与佛罗伦萨断片所记载的以弗所战役、麦加拉战役和诺丁姆战役进行了史料分析和文献比对；在第三章中，笔者对伦敦断片所记内容进行逐条分析并与其他史家的记述进行了文献比对，其中主要探讨了伯罗奔尼撒战争中雅典的衰落与底比斯的繁荣、比奥提亚的联盟体制、伯罗奔尼撒战争之后雅典的复兴、斯巴达霸权的巩固、科林斯战争、罗德斯民主政变、波斯与希腊城邦的关系以及希腊城邦内部的党派斗争等内容。

In a cross-sectional study, the researchers used dual energy X-ray absorptiometry to compare measures of body composition and BMD in 28 girls with Turner syndrome who had neer receied GH and 39 girls who were treated with GH for at least 1 year. Hand radiography was used to compare phalangeal cortical thickness.

在一个代表性的研究中，研究人员利用双能X-线吸收仪分别测量28个没经生长激素治疗的患有Turner综合症的女孩和39个经生长激素治疗至少一年的患有Turner综合症的女孩的机体组分和骨矿物质密度，同时用手X线机测量她们的指皮质厚度。

For strong convective weather , it classified all historical sample events into 4 weather patterns (like northwest , trough area ,west wind and southwest current), established 4 characteristic fields of 400hPa height of HLAFS , then according to the principle of the pattern match calculate and compare the real-time HLAFS forecast products-2-using the similar method inside the big and small key areas , establish forecast equation , finally gain conclusion .To duststrom weather, the historical samples were sorted into duststrom and severe duststrom types in 5 regions (they are whole area, west, central, middle-west and middle-east of Inner Mongolia ),moreover set up different sample databases about ECMWF fields (including 500hPa height, 850hPatemperature and sea-level pressure).In order to making duststrom forecast at different time level , we first filtered the real-time data by FAX data ,and then used the method of similar range degree to compare the historical data to the actual data of ECMWF .To precipitation weather ,they were divided into 2 types that suit or unsuit airplane artificial precipitation stimulation in line with their emergence time and district .The appropriate weather physical factors come from T106 were chosen to establish the artificial precipitation stimulation prediction model . In the actual application , we can get prediction result as long as use the real-time forecast data of T213 in the prediction model .

针对强对流天气将历史样本天气分为西北气流型、槽区型、西风气流型和西南气流型等4个类型，并建立其HLAFS资料400hPa四种特征场，按照模板匹配的原理，用相似分析方法在大、小两个关键区中对实时HLAFS预报产品进行计算、比较，再建立预报方程，得出结论；对沙尘暴天气将其按区域分为全区、西部、中部、中西部以及中东部5类，再按强弱分别分为强和一般2类，建立ECMWF的3个场(500hPa高度场、850hPa温度场和海平面气压场)的历史资料库，在用传真资料消空之后，用相似离度方法计算实时ECMWF资料，做出不同时次的预报；对降水天气按出现时间和区域分为适合和不适合飞机增雨作业2类，选择T106资料中恰当的气象物理量因子，用BP神经网络算法建立人工增雨降水预报模型，实际应用中将实时T213相关预报资料代入预报模型即可。

Don't listen to their haver, nothing of that sort.

别听他们胡说八道，根本就没那回事。

But bank's shares trade below their book value, suggesting that investors are skeptical.

但是，银行股票以低于账面价值的价格交易，这一点反应了投资者的怀疑。