查询词典 L.P.

Tissue ICAM-l was higher in liver cancer than in normal tissue (P.01). Tissue ICAM-l was higher in liver cancer with metastasis than in liver cancer without metastasis (P.01). No correlation was found between tissue ICAM-l and age or sex or tumor grade or tumor dimeter.

结果：30 例原发性肝癌组织 25 例 ICAM－l 表达阳性(阳性率83.3％)，肝癌组织中ICAM-l 含量明显高于正常肝组织(P.01)，转移组肝癌中 ICAM-l 含量明显高于无转移组(P.01)，而与年龄、性别、肿瘤大小、分化程度无关。

Results show that floes' VC and D at the surface water were closely related to current velocity; and the peaks of VC lag those of the current velocity. The lag variation during ebb and flood tides is 10-30min and 30-50 min, respectively. Current velocity at 50 cm/s is a turning point of D vs. vertical average current velocity, before the point, Dm increases with current velocity, and decreases after the point. Similarly, VC at 75μl/L becomes a critical point in the surface water, below the point, D increases with VC, and above the point, D stabilizes.Δp is D dependent, larger floes have much lower Δp than smaller floes. Both D and Δp of floes affect ω. In the surface water during spring tide and neap tide, a power exponent relationship exists between Δp and D, and ω and D.

研究表明：①长江口徐六泾表层絮凝体体积浓度主要受水流流速影响，再悬浮现象明显，体积浓度过程线滞后流速过程线，落潮期间滞后10-30min，涨潮则滞后30-50min；②小于一定流速时絮凝体平均粒径随流速增大而增大，大于一定流速时絮凝体平均粒径则随流速增大而减小，徐六泾夫、小潮表层絮凝体在50cm/s的垂线平均流速时出现平均粒径与垂线平均流速关系的转折；③徐六注大、小潮表层絮凝体平均粒径在体积浓度75μl/L时出现平均粒径与体积浓度关系的转折，体积浓度小于75μl/L时粒径随体积浓度增加而增大，超过75μl/L时粒径随体积浓度的增加变化不明显；④絮凝体有效密度由粒径大小控制，粒径大，有效密度小，反之亦然，粒径和有效密度共同决定絮凝体静水沉速，有效密度和沉速与平均粒径之间均存在良好的幂指数关系。

Our results showed that LMWH at the concentrations of 16000and 8000 u·L(-1) could significantly (P.01, P.05 vs vehicle) inhibit constriction of isolated ileumsmooth muscle of ovalbumin-sensitized guinea pigs induced by OA in vitro, LMWH 200, 50and 12.5 u·kg(-1) ip could markedly (P.01 vs vehicle) inhibit degranulation of Pericranium MC inrats, LMWH 60 and 30 u·kg(-1) ip could significantly (P.01, P.05 vs vehicle) depress the lickingresponse induced by 4-aminopridine and the increasing of capillary permeability induced by aceticacid in mice.

研究结果显示，LMWH16000u·L(-1)（P＜0.01）和8000u·L(-1)（P＜0.05）均能显著降低OA所致的致敏豚鼠离体回肠平滑肌收缩高度；LMWH200u·kg(-1)，50u·kg(-1)和12.5u·kg(-1)（P＜0.01）均能明显抑制颅骨骨膜肥大细胞脱颗粒；LMWH60u·kg(-1)（P＜0.01）和30u·kg（P＜0.05）均能显著减少个氨基毗陡诱发的小鼠舔体反应次数，并能抑制冰乙酸所致的小鼠毛细血管通透性增加。

Results The IC50 of SPG-Rg3 was (155.7±0.71) mg·L-1,when the concentration of SPG-Rg3 was arranged from 37.5 to 600.0 mg·L-1,the growth inhibitory rate of MCF-7 cells was higher following the increase of its concentration,the cell growth was greatly inhibited compared with control group(P.05); cell cycle was changed,the cell number of S period increased compared with control group(P.01),the cell number of G2/M period decreased compared with control group(P.01),in experiment group there was an apoptotic apex before G1 apex,and the number of apoptotic cells increased; most of cell nuleus in SPG-Rg3 (150 mg·L-1)experiment group appeared yellow or chrysoidine fluorescence,contracted,beaded and crescent; the result of immunocellularchemical staining of caspase-8 indicated that caspase-8 protein had no expression in control group,but stronger expression in SPG-Rg3 group.

结果：SPG-Rg3 IC50为（155.70±0.71） mg·L-1，当SPG-Rg3浓度在37.5~600.0mg·L-1时，MCF-7细胞的生长抑制率随SPG-Rg3浓度的增加而增大，与对照组比较，细胞增殖受到明显抑制（P.05）；MCF-7细胞的生长周期也发生变化，S期细胞数增加，明显高于对照组（P.01，G2/M期细胞数则明显少于对照组（P.01；并且在G1峰前出现明显的凋亡峰，凋亡细胞数增加。

Result: At most up to 500 mg·L-1, tetrahydropalmatine showed no sinificant effect on the cell viability; while dehydrocorydaline, berberine and palmatine significantly decreased the cell viability, exceeding 6.3, 0.6 and 6.3 mg·L-1, respectively（ P .05 or 0.01）. Tetrahydropalmatine, dehydrocorydaline, berberine and palmatine significantly inhibited LDH leakage induced by anoxia-reoxia injury, at concentrations of 50-100, 1.25-5, 4 and 30 mg·L-1, respectively（ P .05 or 0.01）. None of the four compounds showed significant effect on the hydrogen peroxide injury.

结果：多至500 mg·L-1的延胡索乙素对细胞活力无任何影响，脱氢紫堇碱、黄连素、巴马汀分别在质量浓度大于6.3， 0.6，6.3 mg·L-1时，显著降低细胞活力（ P 。05或0.01）；延胡索乙素、脱氢紫堇碱、黄连素和巴马汀分别在质量浓度为50～100， 1.25～5， 4，30 mg·L-1时，显著抑制缺氧复氧导致的LDH漏出（ P 。05或0.01）；4种单体对过氧化氢损伤无显著的作用。

Results Lorcainide at concentration of 0.62mg/L,1.25mg/L and 2.50mg/L had a tendency of decreasing the incidence of arrhythmia during ischemia (P＞0.05),and at 1.25mg/L and 2.50mg/L significantly decreased incidence of arrhythmia during early reperfusion (P＜0.05).Its antiarrhythmic effect was accompanied with elevation of subendocardial threshold,significant abbreviation of action potential duratin in subendocardium and subepicardium,and complete or partly delay of transmural conduction time of pulses.

结果 劳卡胺分别在0.62mg/L、1.25mg/L及2.50mg/L剂量时使缺血性心律失常发生率轻度降低(P＞0.05)，后2种剂量使再灌注早期心律失常发生率明显降低(P＜0.05)；降低心律失常发生率同时可提高心内膜下心室肌兴奋阈，延长心内、外膜下心室肌细胞动作电位时程，延迟或部分延迟冲动跨壁传导时间。

Results The activation of NF-κB, proliferation response, and expression of IL-4 and I L-5 mRNA and protein in T lymphocytes stimulated by PMA were significantly hig her than those of their blank control (P.01), while those indexes of T l ymphocytes stimulated by PMA and PDTC simultaneously were significantly lower th an those stimulated by PMA alone (P.01). The apoptotic index of T lympho cytes stimulated with PMA were significantly lower than that of their blank cont rol (P.01), and the apoptotic index of asthmatic guinea pig T lymphocytes stimulated with PMA and PDTC simultaneously were significantly higher than that stimulated by PMA alone (P.01). The significant positive correlations w ere found between the activation of NF-κB and the proliferation (r=0.64, P.001), and the expression of IL-4 and IL-5 mRNA and protein of T lymph ocytes, respectively (r=0.55-0.68, P.001). There was also signific ant negative correlation between the activation of NF-κB and apoptosis of T l ymphocytes (r=0.62, P.001). Conclusions NF-κB may participate in the signal conduction of PKC regulated proliferation, apoptosis and expression of IL-4 and IL-5 of T lymphocytes in asthma.

结果加入PMA培养的哮喘组T淋巴细胞NF-κB的活化、细胞增殖反应、IL-4和IL-5的mRNA和蛋白质的表达均显著高于其空白对照(P.01)，而同时加入PMA和PDTC培养的哮喘组T 淋巴细胞以上指标均显著低于只加入PMA培养的哮喘组T淋巴细胞(P.01)；加入PMA 培养的哮喘组T淋巴细胞的凋亡指数显著低于其空白对照(P.01)，而同时加入PMA 和PDTC培养的哮喘组T淋巴细胞凋亡指数显著高于只加入PMA培养的哮喘组T淋巴细胞(P 。01)。T淋巴细胞NF-κB的活化与增殖反应呈显著正相关(r=0.64，P.00 1)，与IL-4和IL-5的mRNA和蛋白质的表达也均呈显著正相关(r=0.55-0.68，P 。001)，而与凋亡指数呈显著负相关(r=-0.62，P.001)。

Nuttallii propagules germinated normally, but the buds was significantly inhibited (p.05) in growth and the recovery in the subsequent culture was slow. Exposures to 4 mmol/L or higher caused death of E. nuttallii. In contrast, at concentration of 4 mmol/L, all P. crispus buds survived with significant growth and had a good recovery in the subsequent culture; P. crispus turions were remarkably reduced in gerimination rate, but all sprouted in the subsequent culture.

在4mmol/L的乙酸影响下，菹草幼芽仍有明显的生长；菹草繁殖体的萌发受到显著抑制(p.05)，但在随后的培养中可全部萌发。4mmol/L以上的乙酸暴露3d或6d导致伊乐藻全部死亡，8mmol/L的乙酸处理6d或16mmol/L的乙酸处理3d或6d导致菹草全部死亡。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

But the levels of 〓 elevation were lower than that in normal Tyrode's solution (P＜0.01 respectively), indicating that Ca〓 influx did contribute to the elevation of 〓. Ryanodine remarkably blocked the 〓 elevation by Str 1, 100nmol/L and 10μmol/L in normal Tyrode's solution, while ryanodine 10μmol/L, ruthenium red 10μmol/L and caffeine 10 mmol/L completely blocked the effects of Str on 〓 elevation in Ca〓- free Tyrode's solution (P＜0.01 respectively).

去除细胞外液中的钙离子，Str 1，100nmol/L和10μmol/L仍能分别升高〓到13±5％，71±8％和145±14％，但幅度低于其在正常台氏液中的作用。10μmol/L的ryanodine，10μmol/L钌红或10mmol/L咖啡因均可完全阻断Str 1，100nmol/L和10μmol/L在无钙台氏液中的作用(P＜0.01)。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。