查询词典 FAS

Objective:To explore the relationship between Fas antigen and apoptotic rates and pathological mechanism of aplastic anemia.

目的：探讨Fas抗原和凋亡率与再生障碍性贫血发病机制的关系。

Aim To design and synthesize a series of novel γ-butyrolactone derivatives with FAS inhibition activities, C75 as the lead compound.

摘要目的以C75为先导化合物，设计、合成γ-丁内酯类衍生物，并研究其脂肪酸合成酶（fatty acid synthase， FAS）的抑制活性，以期发现新颖的FAS抑制剂。

Objective To study the expression of viral and Fas antigens in the livers of patients with chronic hepatitis Cand their relationship to liver damage and response to interferon therapy.

目的 探讨丙型肝炎患者肝组织中HCV NS5和Fas抗原表达及其与肝组织损伤和干扰素治疗反应的关系。

Methods:The proliferation inhibition of cantharides injections on LoVo cells were detected by tetrazolium.Annexin V-FITC were applied to study cell apoptosis of LoVo cells.FCM were applied to detect the expressions of the Fas and Bcl-2 protein.Results:Cantharides iniections could inhibit the proliferation of LoVo cells and could couse cell apoptosis.

四甲基偶氮唑盐测定药物对LoVo细胞抑制作用与时间和剂量的关系，Annexin V-FITC方法对细胞凋亡进行检测，流式细胞术检测细胞Fas、Bcl-2蛋白表达水平结果：MTT实验表明复方斑蝥注射液可抑制LoVo细胞的生长并诱导发生凋亡。

However it was shown its eventually inhibiting effect on apoptotic myocyte cells during I〓 R〓h (P＜0.05); The PKC inhibitors chelerythrine and scutellarein have no effect on expression of Fas protein, whereas they can significantly upregulate the expression of Bcl-2 protein.

4PKC激活剂PMA可下调Fas基因的蛋白表达，对Bcl-2蛋白的表达也有抑制作用，它对缺血30min、再灌注24h后心肌凋亡细胞的最终影响为抑制效应(P＜0.05)，而PKC抑制剂CHE、灯盏花素对Fas基因蛋白表达无明显干预影响，但对Bcl-2蛋白表达呈显著上调作用，故对心肌细胞凋亡的抑制作用更为明显(P＜0.01)。

In addition, a metabolic inhibitor, actinomycin D has no effect on enzymatic activities of caspase-1/ICE-like and caspase-3/CPP-32/like proteases during Fas-mediated CD4〓T cell apoptosis. These results indicate that the appearance of caspase-1/ICE-like and caspase-3/CPP32-1ike proteases activities is a post-translational activation of these proteases. It is likely these caspases constituently express in a inactive form in the cytosol of CD4〓T lymphocytes. Once the rest SEB-responsive CD4〓T cells are restimulted, those inactive caspases such as caspase-1/ICE-like and caspase-3/CPP32-1ike proteases are sequentially cleaved to become active forms, and the apoptotic signal is transducted to downstream signaling molecules, Finally leads to CD4〓T cells apoptosis.

另外，通过代谢抑制剂放线菌素D对超抗原SEB诱导静息SEB应答〓细胞凋亡过程中Caspase成员酶活性变化的研究表明Caspase-1／ICE样，Caspase-3／CPP32样胱氨蛋白酶并非新合成的信号分子，很可能以无活性方式组成性表达于静息SEB应答〓细胞胞浆，在超抗原SEB再次刺激诱导〓细胞凋亡早期，先后顺序活化，借以传递凋亡信号到下游信号分子，诱导〓细胞凋亡。

The results showed that the surface and cryptal lining cells of the pseudostratified ciliated columnar epithelium and the superficial squamous cells of the metaplastic squamous epithelium both underwent membranous expression of Fas, but the basal cells did not.

为了探讨Fas在鼻咽癌癌细胞凋亡过程中的作用，我们对37例未经治疗的非角化性人体鼻咽癌组织癌细胞Fas表达进行了研究。

When induced by adriamycin, the expression was enhanced and Fas mainly existed in cytochylema.

Fas表达水平的变化可能是体内癌细胞耐药的机理之一。

Inflammatory liver injury during chronic HBV infection is probably not the result of increased numbers of infiltrating CD8+ T-lymphocytes, but of Fas-L expression by Kupffer cells and increased cytolytic activity of cells in portal areas.

在慢性乙型肝炎感染期间炎症性的肝脏损伤可能不是浸润性CD8T淋巴细胞数量增加的结果，但可能是由于枯否氏细胞和门静脉区域细胞的溶细胞活力的增加而引起的Fas-L的表达的结果。

Inflammatory lier injury during chronic HB infection is probably not the result of increased numbers of infiltrating CD8+ T-lymphocytes, but of Fas-L expression by Kupffer cells and increased cytolytic actiity of cells in portal areas.

慢性肝炎过程中的肝损害不是渗透的 CD8+T淋巴细胞增多的结果。而是由枯否细胞表达的Fas-L和增加的细胞病理性活动的结果。

Molecular Distillation is a kind of high vacuum distillation method, which is suitable for the separation of high boiling, heat sensitivity and viscidity products.

分子蒸馏技术是一种在高真空条件下进行的连续蒸馏过程，适合于分离高沸点、热敏性及具有生物活性的混合物。

They are to the Noughties what yuppies were to the Eighties .

那在六十年代是时髦的，但在八十年代肯定是过时了