查询词典 ABL

It is concluded that the value of routine cytogenetical and molecular biological analysis in diagnosis for potential CML cases,which mimicked ET as in this presentation,is very distinctive,and the importance is magnified by the recent availability of imatinib,a specific inhibitor of the bcr/abl tyrosine kinase produced by the Philadelphia chromosome.Every case of

对血小板明显增多的患者应及时进行Ph染色体及bcr/abl融合基因表达水平的检测，这对于ET及CML的诊断和鉴别诊断极为重要，以避免误诊、误治。

Imatinib, a BCR-ABL tyrosine kinase inhibitor, is able to induce a complete cytogenetic response in more than 85% of patients with CML. However, the researchers note that patients with a complete cytogenic response tend to relapse when imatinib is discontinued, and less than 10% of patients achieve a molecular remission, defined by an undetectable residual disease using real-time quantitative–polymerase chain reaction.

Imatinib是一种BCR-ABL酪胺酸激酶抑制物，可以在85%以上的CML病患诱导完整的细胞生成反应；不过，研究者指出，完整细胞生成反应的病患倾向在停用imatinib时复发，不到10%的病患达到分子生物学上的缓解，其定义为以即时定量聚合酶连锁反应侦测不出残余疾病。

Imatinib, a BCR-ABL tyrosine kinase inhibitor, is able to induce a complete cytogenetic response in more than 85% of patients with CML. However, the researchers note that patients with a complete cytogenic response tend to relapse when imatinib is discontinued, and less than 10% of patients achieve a molecular remission, defined by an undetectable residual disease using real-time quantitative–polymerase chain reaction.

Imatinib是一种BCR-ABL酪胺酸激酶抑制物，可以在85%以上的CML病患诱导完整的细胞生成反应；不过，研究者指出，完整细胞生成反应的病患倾向在停用imatinib时復发，不到10%的病患达到分子生物学上的缓解，其定义为以即时定量聚合酶连锁反应侦测不出残餘疾病。

BCR-ABL and mutant JAK2 inhibit the Bcl-x deamidation pathway and the apoptotic response to DNA damage in primary cells from patients with CML or polycythemia vera.

BCR-ABL和突变的JAK2可抑制CML或真性红细胞增多症患者Bcl -×的脱酰胺途径和原代细胞DNA损伤诱导的凋亡反应。

METHODS: We searched for abnormalities of the proapoptotic Bcl-x deamidation pathway in primary cells from patients with chronic myeloid leukemia or polycythemia vera, myeloproliferative disorders associated with the BCR-ABL fusion kinase and the Janus tyrosine kinase 2 (JAK2) V617F mutation, respectively.

我们分别对来自慢性粒细胞白血病或真性红细胞增多症、骨髓增生性疾病相关的BCR-ABL融合蛋白激酶及Janus酪氨酸激酶2 (JAK2) V617F突变体患者原代细胞凋亡前Bcl-x脱酰胺途径的异常情况进行研究。

Dult precursor B2ALL with BCR/ ABL gene rearrangements displays a unique immunophenotype based on the pattern of CD10 , CD34 , CD13 and

ML1/ ETO 融合转录因子在白血病患者化疗及骨髓移植后的追踪观察。中国实验血液学杂志，2001 ；

IM-induced autophagy did not involve c-Abl or Bcl-2 activity but was associated with ER stress and was suppressed by depletion of intracellular Ca2+, suggesting it is mechanistically nonoverlapping with IM-induced apoptosis.

IM诱导的自噬与c-Abl 或 Bcl-2活性无关，但与内质网应激相关并受细胞内Ca2+缺失抑制，提示其与IM诱导的细胞凋亡机制不同。

Aim Chronic myelogenous leukemia bcr abl fusion gene cDNA was cloned and expressed in COS 7 cells.

目的克隆慢性髓系白血病融合基因bcr abl的cDNA序列，并在真核细胞中表达。

The former possibility is supported by the observation that, at least in the laboratory, cell lines resistant to STI571 overexpress BCR-ABL and may show amplification of the fusion gene.

在实验室中发现对STI571有抗性的细胞系过度表达BCR-ABL，并且有该融合基因的扩增，这支持第一种可能性。

Immunohistochemistry analysis with Abl demonstrated the high expression level of CMTM4 in human testis, which was consistent with the previous resuit of Northem blot.

用多肽免疫家兔制备的2种抗CMTM4抗体不仅具有较高的效价以及特异性，并且Ab1还可以特异识别小鼠Cmtm4，为CMTM4的功能研究提供了有力的支持。

That's what makes this mod unique.

这也正是这个MOD独特。

I now feel furious and want to do something.

现在我觉得非常气愤，想做点什么。