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The suspicion of cancer is increased by the following factors:(1) age (young patients are more susceptible);(2) sex, if the patient is a man (more women have thyroid cancer by a ratio of 2:1, but women have more thyroid disease by a ratio of about 8:1; thus, a man with a nodule should be regarded with greater suspicion);(3) a solitary nodule (multinodular lesions are usually benign unless there is a dominant cold nodule by thyroid scan);(4) a cold nodule on thyroid isotopic scanning (hot nodules are seldom cancerous);(5) a history of radiation exposure to the head, neck, or chest, especially in infancy and childhood (eg, for an enlarged thymus or enlarged tonsils, acne, or lymphoma);(6) radiographic evidence of fine, stippled psammomatous calcification or dense, homogeneous calcification;(7) recent or rapid enlargement; and (8) stony-hard consistency.
下列因素可增加癌的可疑性：(1)年龄；(2)性别，如果病人为男性(女性与男性的甲状腺癌比为2：1，但女性更多的是得甲状腺病，约为8：1，因此，男性有甲状腺结节时应考虑癌的可能性更大)；(3)孤立小结(多结节病变一般为良性，除非甲状腺扫描时呈明显的冷结节)；(4)甲状腺同位素扫描时发现冷结节；(5)有过头、颈、胸放射接触史，尤其是婴儿和儿童期(例如，因胸腺增大或扁桃体肿大、痤疮或淋巴瘤等)；(6)X线片见细、斑点状、沙粒样钙化或致密、匀质钙化；(7)最近增大或快速增大；(8)质地石头样坚硬。
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objective to investigate staining methods for two-dimensional gel(2-de)electrophoresis in multidrug resistance of gastric cancer.methods cultured vincristine-resistant human gastric cancer cell line sgc7901/vcr and its parental cell line sgc7901.variant amount protein of those cells were separated by 2-de.gels were stained with silver nitrate or colloidal coomassie brilliant blue,and scanned by image scanner.results well-resolved,reproducible 2-de patterns of sgc7901/vcr and sgc7901 were established.silver staining was better when protein sample amount was low,overloaded protein will interfere resolution of the maps.gels stained with colloidal coomassie brilliant blue had more protein spots numbers and abundance without apparent trails when increased loading protein sample.conclusion two staining methods were influenced largely by the sum of protein samples,properly selection may be helpful for further study with proteomics in multidrug resistance of gastric cancer.
低甲氧基果胶的胶凝机理及防止预凝胶。。。他扎罗汀凝胶与克林霉素凝胶治疗痤疮。。。注射隆乳后经乳晕切口取出聚丙烯酰胺。。。目的分析利用蛋白质组学方法研究胃癌耐药相关蛋白质中双向电泳凝胶的染色显示。方法培养胃癌细胞sgc7901和长春新碱诱导的耐药胃癌细胞sgc7901/vcr，用双向凝胶电泳技术分离总蛋白，银染及胶体考马斯亮蓝染色，image scanner扫描仪扫描凝胶。结果获得了背景清晰、重复性好的双向凝胶电泳图谱，两种染色凝胶相比，硝酸银染色在样品少时显示更佳，过量则影响图像质量，而胶体考马斯亮蓝染色在上样量增加时的凝胶蛋白质点数目及丰度均增加，并无明显拖尾。结论两种显色方法受样品量影响较大，恰当选用有利于通过蛋白质组学研究胃癌耐药机制工作的进一步开展。
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acmesthesia：(心)尖锐感觉
acmaea 笠贝属、帽螺 | acmesthesia (心)尖锐感觉 | acneform 痤疮样的
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acneform：痤疮样的
acmesthesia (心)尖锐感觉 | acneform 痤疮样的 | acnerosacea 红斑痤疮 、酒渣鼻
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lupoid：狼疮状的 类狼疮
lupinotoxin 羽扇豆毒素 | lupoid 狼疮状的 类狼疮 | lupoidacne 狼疮样痤疮
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lentigines：痣
Adapalene是一种新的维甲酸制剂,除了痤疮外,该产品还可用于光化角化病(Actinic keratoses)和雀斑样痣(lentigines)的治疗. Adapalene(Differin)是一种治疗寻常痤疮的维甲酸药物.