重激活

Experiments show that Ang Ⅱ activates JNK mediated by AT〓, and JNK increases transcription activity of c-Jun by phosphorylating c-Jun amido-terminal, and induces expression of c-Fos gene. c-Jun and c-Fos form transcriptional factor activated protein-1 complex. AP-1 may stimulates genes which correlate with cardiovascular remodeling expression, such as transforming growth factor, collagen type Ⅰ and Ⅲ, skeletal muscle α-actin,β-MHC, atrial natriuretic factor.

实验表明，在心肌和血管平滑肌细胞Ang Ⅱ通过AT〓介导激活JNK；JNK通过磷酸化c-Jun氨基末端增加c-Jun的转录活性并诱导c-Fos基因表达，c-Jun和c-Fos蛋白形成转录因子复合物激活蛋白-1(AP-1)，并刺激各种心血管重塑相关基因如转化生长因子-β1(TGF-β1)、Ⅰ，Ⅲ型胶原、骨骼肌α-actin、β-MHC(β-myosin heavy chain，β-肌球蛋白重链)、心钠素的表达。

The one in which there was no activation was the heaviest.

没有被激活的是最重的一个。

The tree can be opened to any level of nesting, and the top level can be relocatable to any directory on the local computer. To call xffm with only the local files branch activated, use xftree4 as the command line.

这个树能打开至任意深度的嵌套，并且顶部能被重定位至本地计算机的任何目录。call xffm本地文件分支激活，在命令行使用xfree4

Through his photographic reenactment of history, though his return to the historical stage, his footsteps touch on our memories, stimulating our consideration of reality.

通过他的重新拍摄历史，通过他的步入历史重归现场，他的脚步触动的是我们的记忆，激活的是我们的现实思考。

When coming in the winter, the enterprise has renascence type " popular feeling activations ", it is necessary not only, and proper meantime.

在冬天来临之际，企业进行一次重生式的"人心激活"，不仅是必要的，而且正当其时。

It can highly keep the moisture, lock up the nutrition and make the skin recover to its natural spring and shininess and delay aging, gives you a bright and radiant appearance.

可持续淡化黑斑和雀斑，并抑制黑色素生成，促进皮肤亮白透彻并均匀肤色，激活细胞重生，从而恢复肌肤弹力，重现肌肤活力，为您缔造更白皙细腻的理想肌肤。

Abstract］ objective to observe the therapeutic effect and safety of low dose recombinant tissue-type plasminogen activator,urokinase and recombinant streptokinase in embolism therapy for acute myocardial infarction.

摘要］ 目的观察小剂量重组织型纤溶酶原激活剂、尿激酶和重组链激酶治疗急性心肌梗死的疗效和安全性。

Key words］ low dose recombinant tissue-type plasminogen activator;urokinase;recombinant streptokinase;acute myocardial infarction

关键词］小剂量重组织型纤溶酶原激活剂；尿激酶；重组链激酶；急性心肌梗死

That's because we learned to tighten up our own internal weight belt on exercises verses using an external weight belt that shut off the need to activate the TVA which lead to injuries.

那是因为我们的经验教训，以加强我们自己的内部重量带演习诗句使用外部重带，关闭需要激活的TVA导致人员伤亡。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后，在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加，包括肾小球病和球外疾病等。