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Objective To explore the effect of high serum concentration of bile acids on energy metabolism of liver.Methods Bile acids were continously infused into the Wistar rats to simulate the serum concentration change of patients with obsturctive jaundice.Serum bile acids concentration,arterial blood ketone body ratio and energy charge of liver were determined.Results Aterial blood ketone body ratio and energy charge of liver decreased with the increase of serum bile acids concentration.Conclusion High serum concentration of bile acids plays an important role in hepatic fumction injury caused by biliary obstruction.

目的 探讨高胆汁酸血症单一因素对肝脏能量代谢的影响方法经Wistar大鼠颈内静脉持续给予外源性胆汁酸,升高其外周血清中胆汁酸浓度,模拟阻塞性黄疸患者外周血清中胆汁酸的变化规律,观察腹腔动脉血酮体比值及肝组织能荷变化,时间一周结果随外周血清中胆汁酸浓度的升高,腹腔动脉血酮体比值、肝组织能荷均呈进行性下降结论高胆汁酸血症时肝脏能量代谢受损,表明在阻塞性黄疸患者肝功能损害中高胆汁酸血症起了重要作用

In this paper, the effects of different catalyst combinations on the synthesis of α-chloro-dodecanoic acid were investigated, in which a series of acyl chlorides such as 4-toluene sulfonyl chloride, dodecanoyl chloride, chlorosulphonic acid , etc.

本文从烯酮式反应机理出发,以α-氯代十二酸的合成为模型,对酰氯化试剂(对甲苯磺酰氯、十二酰氯、氯磺酸等)和质子酸催化剂(如H型离子交换树脂、氯磺酸、对甲苯磺酸、醋酸等)进行组合和选择,并与文献报道的特殊添加剂乙酐比较,研究不同催化体系在酸催化合成α-氯代脂肪酸时的催化作用。

Results\ The levels of some essential amino acids like valine,leucine and histidine were significantly lower than those of normal controls.

结果 血透患者在透析前的必需氨基酸除苯丙氨酸外均较正常对照组降低,其中以缬氨酸、亮氨酸和组氨酸下降为显著;非必需氨基酸中精氨酸、甘氨酸和鸟氨酸明显升高;酪氨酸/苯丙氨酸和丝氨酸/甘氨酸的比值较对照组明显降低。

Results showed that the RFAs in DCS of Masson pine CTMP were mainly composed of oleic acid,linoleic acid,DHA,pimaric acid,abietic acid and oxidized products of DHA.The ratio of fatty acids to resin acids in FR-DCS,CTMP-DCS,BCTMP-DCS were 1:2.8,1:2.1 and 1:3.8,respectively.

结果发现,马尾松化机浆DCS中的脂肪酸主要有油酸、亚油酸等,树脂酸主要有脱氢枞酸、海松酸、枞酸以及脱氢枞酸氧化物等;一段磨后浆、漂前浆、过氧化氢漂后浆DCS中脂肪酸与树脂酸的比例分别约为1:2.8、1.2:1、1:3.8。

In the absence of organic solvent and phase-transfer reagent, the catalytic oxidation of cyclo- hexene to adipic acid with aqueous 30% hydrogen peroxide can be achieved in the presence of tungstic acid/acidic organic additive.

以钨酸/有机酸性添加剂为催化体系,在无有机溶剂、相转移剂的情况下,催化 30%过氧化氢氧化环己烯合成己二酸。当钨酸∶有机酸性添加剂∶环己烯∶过氧化氢=1∶1∶40∶176(摩尔比,钨酸用量为 2.5 mmol)时,使用有机酸性添加剂考察钨酸的催化性能,结果表明以钨酸/间苯二酚催化氧化环己烯的催化效果最优,反应 8 h 时己二酸分离产率达 90.9%、纯度为~100%;而不使用有机酸性添加剂时,己二酸分离产率只有 72.1%,产品纯度为 96.2%。

The patients with methylmalonic acidemia and homocystinuria should be mainly treated with vitamin B12, betaine and L-carnitine, while the patients with isolated methymalonic acidemia should be treated with protein restriction, the special milk formula without isoleucine, valine, methionine, and threonine, and be given L-carnitine.

对伴有同型半胱氨酸血症患儿,治疗以维生素B12、甜菜碱和左旋肉碱为主;对不伴有同型半胱氨酸血症患儿以限制天然蛋白质摄入,给予去除异亮氨酸、缬氨酸、甲硫氨酸和苏氨酸的特殊奶粉及左旋肉碱治疗为主。

As results, the contents of three original pimaric-type resin acids, namely pimaric, isopimaric and sandaracopimaric acids, generally decreased, the higher the initial content with the higher the temperature and longer time, the faster the content declined.

结果表明,脂松香中原有的3种海松酸型树脂酸即海松酸、异海松酸、山达海松酸的含量总体呈下降趋势,初始含量越高、热处理温度越高、时间越长,其含量下降幅度越大。

The results showed that the phosphotungstic had better catalytic activities than the silicotungstic acid. As for the supported HPAs, the silica gel support HPAs' catalytic activities were higher than the activated carbon support HPAs.

实验结果表明:对于非负载型杂多酸催化剂,磷钨杂多酸的催化活性要高于硅钨杂多酸;对于负载型杂多酸催化剂,硅胶负载杂多酸催化剂的催化活性要高于活性炭负载的杂多酸催化剂。

Eight phenolic acids in Satsuma mandarin during maturity were determined by high-performance liquid chromatography coupled with photodiode array detector in this study, which were:protocatechuic, p-hydroxybenzoic, vanillic, caffeic, p-coumaric, ferulic, sinapic and chlorogenic.

采用HPLC-PDA测定了不同成熟期温州蜜桔中八种酚酸的含量,即绿原酸、咖啡酸、对香豆酸、阿魏酸、芥子酸、原儿茶酸、对羟基苯甲酸和香草酸。

Results: Good linearity was observed in 6~1512μmol.L-1 range for phenylalanine, the intra-run and inter-run imprecisions w ere 3.68%and 4.01%, the recovery rate was 98.6%; good linearity was observed in 5.4 ~1380.0μmol.L-1 range for tyrosine, the intra-run and inter-run i mp recisions were 1.87%and 2.59%, the average recovery rate was 98.9%.

酪氨酸的线性范围为5.4~1380μmol.L-1,最低检测浓度为0.7。μmol* L-1,平均回收率98.9%,批内CV为1.87%,批间CV为2.59%。健康儿童血清苯丙氨酸浓度为(61.4±10.8)μmol.L-1,血清酪氨酸浓度为(131.8±28.0)μmol.L -1。健康成人血清苯丙氨酸浓度为(69.3±8.6)μmol.L-1,血清酪氨酸浓度为(83.6±9.4)μmol.L-1.4例苯丙酮尿症患儿的血清苯丙氨酸浓度为1296~1759μmol.L-1,血清酪氨酸为29.5~53.5μmol.L-1。

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