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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

The DSC results showed that calcium carbonate,sodium benzoate and terephthalic acid were the nucleating agents of polypropylene with high thermal stability of the nucleating effect,while the thermal stability of nucleating effect of pimelic acid,suberic acid,azelaic acid,and the two component nucleating agents suberic acid/calcium carbonate and azelaic acid/calcium carbonate were poor.

研究了碳酸钙、苯甲酸钠、对苯二甲酸和脂肪二元酸:庚二酸、辛二酸、壬二酸及其与碳酸钙组成的双组分成核剂对聚丙烯结晶成核效果的热稳定性。结果表明,高熔点物质碳酸钙、对苯二甲酸、苯甲酸钠的成核效果的热稳定性高,而脂肪二元酸的成核热稳定性低。庚二酸与碳酸钙组成的双组分成核剂的成核热稳定性高,但辛二酸、壬二酸与碳酸钙组成的双组分成核剂的成核热稳定性没有得到改善。

The thesis toke problem of deformation and destroying of the earth mass as it's invention, integrated the earth mass's existing environment, ingredients and macrostructure, discovered mechanism of deforming and destroying, made clear the relationships between those.Through outdoors samples, indoors examination surface wave testing and audio wave testing ,do some research on physical, mechanical, chemical, disintegrative and dynamics property of stuff of earth mass and proposed four kinds of earth mass's stuff formed type;under the guidance of theory of dominant structural surface and adopting precision measurement of structural surface, proposed three dominant kinds of structural surface assembling;based on those , proposed four types of earth mass's deformation and destroying, carried out rationed estimation of stability on four types, then definite the characters of deforming and destroying and controlled relation between environment , stuff, macrostructure and deformation and destroying of mass earth, and breakthrough ordinary principle about soil's deformation and destroying, further proofed the theory of earth mass cybernetics's popularization

本学位论文针对台地危险土体的变形破坏问题,将土体的赋存环境、土体物质组成和土体宏观结构的研究紧密地结合,阐明了土体变形破坏的机制,明晰了土体变形破坏与土体的赋存环境、土体材料组成、土体宏观结构三要素之间的关系,并从土体的物质组成的角度,以野外取样、室内实验、现场面波、声波无损伤测试为手段,研究了土体物质的物理、力学、化学、矿物、崩解性、动力学性质,提出了研究区内土体物质成分的四种组合形式;以优势结构面理论为指导,以结构面的精确测绘为手段,通过统计、归纳与分析,提出三种有利于台地危险土体变形破坏的优势组合形式;据此提出了具有广泛代表意义的台地危险土体变形破坏的四种模式,并对其进行稳定性评价,从而明确了危险土体的宏观结构对变形破坏的控制作用,映证了土体结构控制论。

The method according to claim 6, for manufacturing a blade wherein a part external to the shell comprises a blade rooting part having at least one attachment bar, in which an end portion for linkage to a hub of said rotor is fitted with a laminate attachment, also comprising thermoplastic composite, and extending said at least one spar bar housed in the shell, the method further comprising the step of producing the elementary piece comprising the at least one spar by producing each attachment bar and the spar bar in the form of a strip of continuous and unidirectional reinforcing fibres which are agglomerated by said thermoplastic matrix, obtained by pultrusion at a melting temperature of the matrix, of several plies of continuous and unidirectional fibres which are agglomerated by said matrix, and, if said rooting part comprises at least two attachment bars, each one of which respectively extends one spar bar, in superimposing parts of corresponding strips forming the spar part housed in the shell, with interposition of at least one ply of continuous and unidirectional fibres which are agglomerated by said matrix between the adjacent superimposed strip parts, and fitting a removable tool, in the shape of a wedge, between parts held spaced from each other of two neighbouring strips, to form two attachment bars of the rooting part, then arranging the strips in a mould, and inserting each linkage end portion of a pultruded strip between two laminate elements of the attachment, to superimpose all the laminate elements of the attachment, closing the mould and compacting its contents under pressure and at a melting temperature of said thermoplastic matrix, and solidifying the matrix by cooling to rigidify the spar thus obtained with the laminate attachment solidly attached to its rooting part.

该方法根据索赔六,制造业刀片其中的一部分,罐壳外部包括一个叶片生根的一部分,拥有至少一个实习酒吧,在其中一结束部分为联系枢纽的说,转子是带有附件的层压板,也包括热塑性复合材料,并延长说,至少有一石酒吧住在蚬壳公司,进一步组成的方法步骤,生产初级一块组成的至少有一个SPAR公司生产每个附件的酒吧和酒吧在SPAR公司的形式,带不断加强和单向纤维是由烧结说,热塑性矩阵,得到的拉挤在熔化温度矩阵,数层的连续和单向纤维是由烧结说,矩阵,如果说,生根部分组成,至少有两个实习酒吧,每个人都分别延长一石酒吧,在叠加部分,相应的带形成的SPAR公司的一部分,居住在蚬壳公司,与干预的至少有一单层连续和单向纤维是由烧结说,矩阵之间的毗邻叠加条形零件,及装修一个可移动的工具,在形状,离间,部分之间举行的间隔从对方的两个邻国带,形成两个附件酒吧的生根部分,然后安排带在一个模具,并插入每个联系年底部分一拉挤带之间的二板的要素扣押,叠加所有层压板的要素扣押,关闭模具和压缩其内容的压力下和在熔化温度说,热塑性矩阵,并巩固矩阵冷却 rigidify该SPAR公司,从而获得与层压板的附着牢固重视其生根的一部分。

The invention relates to a composite high-temperature electric heating element and relative producing method, which is formed by graphite, carbon silicon and molybdenum silicide.

本发明公开了一种复合高温电发热元件及其制作方法,它是由石墨、碳化硅和二硅化钼三种材料复合组成的电发热元件;在将石墨、碳化硅和二硅化钼三种材料复合组成电发热元件时,将石墨作为基础层,在石墨基础层上先覆盖上碳化硅层,然后再在碳化硅层上覆盖上二硅化钼层。

The =/.../g syntax decomposes the string of digits into a list of strings, each three digits long.

g语法将整个数字串分解成一个由字符串组成的列表。每个字符串由三个数字组成。

A comparison analysis of muscle chemical compositions such as proximate analysis, amino acid profiles and fatty acid composition of wild and pond-farmed Hemibarbus maculates was conducted.

通过对野生花和池养花肌肉中常规营养组成、18种氨基酸含量及脂肪酸组成的比较分析。

Rresults from those studies can be summariazed as follow:(1) A preliminary study no correlationship between the UV-VIS reflection spectrum of tomato fruit surface and the lycopene amount of tomato fruit was undertaken. Based on observation from this study, a damage-free and in-situ detection technique of lycopene amount from tomato was developed with UV-VIS reflection spectroscopy;(2) The geometrical isomers of lycopene were separated successfully on C30-HPLC-PDA-ELSD. The absorption coefficients of Z-isomers were consequently dedermined. The geometrical isomer composition of lycopene could therefore be assessed. Those efforts formed a solid base to identify the natural product from synthetic compound of lycopene;(3) Lycopene resource from the fruit of Autumn oliver was proved to be available for industrial application. An extraction methos of lycopene from the fruit of Autumn oliver by supercritical carbon dioxide was developed at laboratory scale;(4) A method to extract lycopene by supercritical liquid with improved efficiency was developed; Data from this investigation suggested that a proper raw material pre-extraction process was important for a better extraction efficiency;(5) Variation in the geometrical isomer composition of lycopene during its metabolish in rat was assessed. A large amount of Z-isomers were observed. This variation took place in serum;(6) The absorption rate and accumulation in serum of natural lycopene in rat were assessed;(7) Ability to quench singlet oxygen by different geometrical isomers of lycopene was compared;(8) It was detected that whether natural lycopene had functions to regule blood-lipids and LDL antioxidation;(9) A C31 degradation piece of lycopene was found in the prostate gland of rat.

研究结果包括:[1]应用UV-VIS反射光谱法建立了番茄果实中番茄红素含量的无损伤、现场检测技术;[2]应用C30-HPLC-PDA-ELSD技术实现了对番茄红素几何异构体的分离,测定了不同顺式异构体的吸光系数,建立了天然番茄红素几何异构体组成的检测方法,为区分和鉴定人工合成品和天然产物奠定了基础;[3]证实了秋橄榄果实中的番茄红素资源具有工业开发价值,并建立了超临界CO_2萃取的实验室方法;[4]探索了提高番茄红素超临界流体萃取效率的方法,证明了物料前处理对提高萃取效率起了极其重要的作用;[5]观察了番茄红素在大鼠体内几何异构体组成的变化情况,发现了大量顺式异构体的存在,并证实了几何异构体组成在血清中发生了显著变化;[6]测定了天然番茄红素在大鼠体内的吸收率和在大鼠血清中的动态积累规律;[7]比较了不同番茄红素几何异构体淬灭单线态氧的能力;[8]检测了天然番茄红素是否具有调节血脂作用和抗低密度脂蛋白氧化的功能;[9]首次发现大鼠前列腺内存在番茄红素C31降解片段,并证实其仍具有淬灭单线态氧的能力。

Based on determination of the components of naphthas by gas chromatography,we make use of near infrared spectrum and stoichiometry to build up a quick,precise analytical approach to determine the composition of naphthas.

以气相色谱法测定石脑油族组成为基础,采用近红外光谱和化学计量学方法建立了快速、准确测定石脑油族组成的分析方法。

One drift tube with the dimension of 25 mm×10 mm×1 mm is composed of two copper planar electrodes, the other with the dimension of 20 mm×10 mm×1.5 mm is fabricated by Micro Electro-Mechanical System technology.

加工了两种由两平行金属极板组成的迁移区,一种由两平板铜块组成,尺寸为25 mm×10 mm×1 mm;另外一种由微机电工艺加工,尺寸为20 mm×10 mm×1.5 mm。

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He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后,在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加,包括肾小球病和球外疾病等。

Pagans and partygoers greeted the summer solstice at the ancient stone circle of Stonehenge.

异教徒和社交聚会常客在史前巨石柱的古老的石圈附近庆祝夏至。