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Modified antisense PNA, electrostatically bound to the surface of specifically designed polymeric coreshell microspheres.

通过对反义肽核酸的修饰，促使其与特殊设计的聚合的核壳型微球结合。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Taken together, the results indicated that a small number of genes specifically or elevatedly expressed in particular organs or tissues are directly correlated to the adaptation evolution of four reed ecotypes.

这些结果提示少数基因在特定器官的高效表达与不同生态型芦苇对环境的适应直接相关。

VEGF can specifically increase the dividing, proliferation and movement of endotheliocyte, as well as the permeability of tumor vessels, making it a crucial angiogenic factor in research.

血管的生成机制中，血管内皮生长因子(vascular endothelial growth factor，VEGF)是重要的直接作用于血管内皮细胞的生长因子，可以特异性地促进内皮细胞分裂、增殖、移动，增加血管的通透性，在血管形成中起重要作用，是目前特别受重视的血管生成因子之一。

Recombinant CD 59 protein using ICAM-2 promoter with enhancer can be exlSt:essed highly, effectively and specifically in PAECs and transgenic mice.

以人细胞间黏附因子Ⅱ(ICAM-2)为启动子并带增强子的CD59重组基因在猪的血管内皮细胞及小鼠体内均高效特异表达。

Q: (Livio Oricchio O Estado de Sao Paulo) Alonso, you said your team needs to work specifically in some areas of the car, which suggests you know exactly what you have to do, and also, you are three points behind the leader of the championship, in spite of all the problems you have experienced this weekend.

Alonso，你说车队需要在赛车的某些方面做工作，这说明你们知道具体要做什么，而且尽管周末经历了这所有问题，你现在落后于积分榜的领先者3个积分。

Specifically,they embrace its value,theoretical basis,and types of system,legal property,component parts,comparisonwith related systems,and the relevance of extinctive prescription.

具体包括物权请求权的制度价值、理论根据、类型体系、法律性质、构成要件、与相关制度的比较、是否适用消灭时效等问题。

Depending on what type of paint you're working on, traditional paints like lacquers and enamels, or catalyzed clear coats, Meguiar's has the products specifically designed to work on both types of paints, not to mention many other surfaces such as plastics and polyester resins (Fiberglas Gel-coats).

取决於你进行工作的漆面种类，传统漆层如亮光漆和瓷漆或经催化的透明涂层，美克拉的产品经过特别的设计可以使用在任何种类的漆面上，更别提其他像塑胶和聚酯树脂这类表面了

Specifically, the aim was to test the effects of FGF-1 on the angiogenic, fibroblastic, and epithelial responses in a wound model.

具体地说，目的是在angiogenic上测试FGF-1的作用，纤维原细胞，并且在一个创伤模型的皮膜的回答。

Lexan 9030FR sheet has been specifically developed to meet the flammability requirements of the European building and construction market.

Lexan 9030FR 板材是为了满足欧洲建筑市场的对阻燃性需求而特别开发的。

I'm strongly against the death penalty — it's an eye for an eye.

我不赞成死刑——这是以牙还牙的报复行为。

And to get you the support you need, we're enlisting all elements of our national power: our diplomacy and development, our economic might and our moral suasion, so that you and the rest of our military do not bear the burden of our security alone.

并给你们所须的支援，我们正徵召国家所有各种的力量：我们的外交及发展，我们的经济力量与道德劝说，所以你们与其他军人不须要孤独地负起国家安全的责任。