查询词典 signaling

Janus protein tyrosine kinase-signal transducer and activator of transcription signaling pathway may be one of the most important signaling pathway to control the biological states of thrombi.

Jak蛋白酪氨酸激酶－信号转导子和转录激活子信号通路可能是调控血栓的生物学状态的重要信号通路之一。

Furthermore, we found that the Sema3F-triggered growth cone attraction was abolished by inhibition of the cGMP signaling pathway but not by inhibition of the cAMP signaling pathway, and the attraction was suppressed when elevating the intracellular cGMP level.

而且，在组织块共培养中，分泌Sema3F的细胞团能使小脑颗粒细胞偏向它迁移。我们发现Sema3F的吸引性作用在cGMP信号通路被抑制时受阻断，在细胞内cGMP水平增加时被削弱。

On the basis of the railway organization simulation system of PDL, this paper takes the under-constructing Beijing-Tianjin Passenger Dedicated Railway Line as background. Simulation experiments are respectively carried out using traditional way and accurate simulation initialization method in four-aspect fixed block signaling system and quasi-moving block signaling system.

最后在自主设计开发的客运专线列车运行组织仿真系统上，以正在建设的北京到天津客运专线为背景，分别应用传统的和精确的初始映像方法在四显示固定闭塞和准移动闭塞下进行仿真。

ConclusionOur datas showed that Ihh and PTHrP signaling way are highly express in PSCs andmay play an important role in rats\' epiphyses entochondrostosis process. They form anIhh-PTHrP signaling axis with an interaction of negative feedback ring.

在软骨膜来源的前软骨干细胞中也存Ihh和PTHrP信号通路，两者构成Ihh-PTHrP信号轴，并通过负反馈调节机制相互影响和制约，以独立或协同的方式对细胞的增殖和分化发挥关键性调节作用。

1、Cur inhibits K562 cells growth and induces cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as p-Erk1/2、c-myc which are relevant with cell growth and apoptosis; 2、Cur synergizes STI571 to inhibit K562 cell growth and induce cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as Hsp90、PKC which are relevant with cell growth and apoptosis; 3、Cur reverses the resistance of K562/G01 cells to STI571, and synergizes STI571 to inhibit K562/G01 cell growth and induce cell apoptosis; 4、Cur inhibits human originated CML CD34~+ cell growth、induces cell apoptosis, and enhances STI571 to down-regulate the expression of p210~, finally inhibit cell growth and induce cell apoptosis.

从以上实验结果我们得出如下结论： 1、Cur抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游p-Erk1/2、c-myc等信号分子有关； 2、Cur协同STI571抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制Hsp90和下游PKC等信号分子有关； 3、Cur可逆转K562/G01细胞对STI571的耐药性，并与STI571协同抑制K562/G01细胞增殖和诱导凋亡，其抑制K562/G01细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游Procaspase-3和NF-κB等信号分子有关； 4、Cur可抑制来源于CML患者骨髓的CD34~+细胞的增殖并诱导其凋亡，还可协同STI571下调CML CD34~+细胞p210~表达，进而协同抑制细胞增殖、诱导细胞凋亡。

The invention provides a method and device for networking using M3UA protocol and message forwarding. The method comprises following steps configuring every signaling point as direct connection, quasi- direct connection office direction; configuring data for direction connection and quasi direction connection; routing for signaling message for message forwarding.

本发明提供了一种使用M3UA协议组网及消息转发方法和装置，该方法包括以下步骤：按照组网需求将各个信令点分别配置为直连、准直连局向；为直连和准直连局向进行数据配置；为信令消息选路以进行消息转发。

A cell is not just a well-mixed container of chemicals, but an extremely intricate system of membranes, vesicles and signaling pathways. Although a number of milestones have been built though endeavor for over a century, much is still left to discover about the spatial organization and mobility of macro-molecules (such as proteins, protein complexes, nucleic acids, signaling substances, etc.) in cells, and the spatial relationships between cells in tissues.

细胞不仅是大量化学物质的容器，也是膜、泡囊和信号传导通路组成的复杂系统，尽管通过一个多世纪的努力，细胞生物学研究取得了若干重大进展，但是关于细胞内特定高分子(如蛋白质、蛋白质复合体、核酸和信号传导物质等等)的空间组织和运动规律以及组织内细胞空间关系等许多问题的机理目前仍不清楚。

Hes5 gene, a key downstream mediators of Notch signaling that functions by inhibiting the expression or activity of positively acting bHLH factors, is a member of bHLH transcription factor family which acts as a positive-negative transcriptional regulators which is expressed transiently in different stages in cells growth and differentiation and orchestrate those precisely timed and progressive maturational events underlying cell fate decisions according to orders of time and spatial and coordinated the function of majority of signaling transduction on target genes to influence the proliferation and differentiation.

Hes5是Notch通路转导途径的一个关键的下游信号分子，通过抑制正调控bHLH因子的表达和活性来发挥作用，隶属于碱性螺旋-环区-螺旋转录因子家族。该家族形成一个正负转录调节器，按时空顺序短暂表达于细胞发育分化的不同阶段，介导和协调多种信号系统对大量靶基因的作用，影响细胞增殖、分化。

Here we reviewed current understanding of the HH signaling mechanisms that governs the establishment of the HH gradient and the transduction of the HH signaling with an emphasis on the intr...

近年来通过对其信号传导途径深入研究，发现HH信号的异常与人类肿瘤形成有密切的联系，有可能为肿瘤的诊断和治疗提供新途径。1 HH信号途径1.1 H

Fibronectin is a very important biological molecule in collagen glucoprotein that plays a number of important roles in the extracellular matrix. It has roles in structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, cell contractility, epithelial tissue repair, alignment regularization and organism immunoregulation.

纤维连接蛋白(fibronectin，FN)是一种具有重要生物学活性的非胶原糖蛋白，是细胞外基质(extracellular matrix，ECM)的重要组成部分，参与机体的细胞连接黏附、增殖分化、信号传导、基因表达、收缩调节、上皮组织修复、排列规则化以及机体免疫调控等重要的生理功能。

Methods: Five patients with parkinsonism or dystonia were assigned to general anesthesia using an modified endotracheal tube.

本实验依照人体实验之相关规定进行，五位患有帕金森氏症或肌张力异常的病人接受神经立体定位手术。

If you can benefit from this book, it is our honour.

如果您能从本书获益，这将是我们的荣幸。