查询词典 quinolinic

Alzheimer′s disease animal models were made by damaging bilateral nucleus basalis of Meynert of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase was measured by radiochemistry assay. One time training passive avoidance step-down and water-maze spatial localization task were used to observe effects of ginsenoside of stem and leaf in combination with choline on learning and memory of AD model rats.

应用喹啉酸（每侧150 nmol，2 μL，给受试药后d 3注射）损毁老年大鼠双侧Meynert基底核制备阿尔茨海默病动物模型，放射化学法测定胆碱乙酰基转移酶活性，一次性训练被动回避跳台实验和水迷宫空间分辨能力测试，观察人参茎叶皂甙和胆碱合用对AD模型大鼠学习记忆的影响。

Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.

通过腹腔注射药物东莨菪碱或亚硝酸钠，或者用奎宁酸损毁大脑海马CA 1 区诱发大鼠发生记忆力障碍，造成不同类型的大鼠&痴呆&模型，对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参数的变化。

Li Zhongren,Shen Meihong,Mu Yanyun,et al.Nanjing University of TCM,Jiangsu210029. Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.

目的 探索临床针刺加当归芍药散治疗阿尔采默氏症的可能机理方法通过腹腔注射药物东莨菪碱或亚硝酸钠，或者用奎宁酸损毁脑海马CA 1 区诱发大鼠发生记忆力障碍，造成不同类型的大鼠&痴呆&模型，对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参的变化。

High quinolinic acid levels in the brain are thought to be the cause of the dementia seen with HIV infection.

高喹啉酸水平在大脑中被认为是造成痴呆看到感染了艾滋病毒。

Investigate the efftects of exogenous quinolinic acid on acute and subacute animal models of inflammation.

研究外源性给予喹啉酸对动物急性和亚急性炎症模型的影响。

Objective: To study if Lomerizine protects the hippocampus neurons cultured in vitro from the injury caused by quinolinic acid.

目的：利用洛美利嗪研究钙离子拮抗剂对兴奋性氨基酸喹啉酸所致体外培养海马神经元损伤是否有保护作用。

Quinolinic acid ; hippocampus ; glutamate ; Alzheimer's ; disease ; learning ; memory.

喹啉酸；海马；谷氨酸；阿茨海默病；学习；记忆

Quinolinic acid is an endogenous neurotoxin, that activates the N-methyl-D-aspartate receptor and the biosynthesis of NAD+ precursor.

Quinolinic acid是一种内生性的神经毒素，活化N-methyl-D-aspartate接受器以及在生物合成NAD+的前驱物。

The purpose of this research is to discuss the probable mechanism of acupuncture treatment combined with pharmacotherapy regulating glutamatergic function and anti-free radical effect on the dementia rats due to hippocampal CA, lesions induced by quinolinic acid. So that the author can provide the clinical application of acupuncture treatment combined with pharmacotherapy with experimental evidences in treating Alzheimers disease.

本文的研究目的是探讨针药结合对喹啉酸(Quinolinic Acid，QA)损毁海马CA_1区所致痴呆大鼠模型的中枢兴奋性神经递质谷氨酸(glutamate，Glu)和抗氧化指标的影响及其对提高痴呆大鼠学习记忆能力的可能机理，为临床针药结合治疗阿尔茨海默氏病(Alzheimers disease，AD)提供实验依据。

XC7201 is an interesting protein comprising 176 amino acids. Many sequences in the prokaryote and eukaryote kingdom with high similarity score were detected by BLAST search. It was predicted to a 3-hydroxyanthranilate 3,4-dioxygenase (3HAO), which is an extradiol dioxygenase that catalyzes the final conversion step of tryptophan to quinolinic acid in the kynurenine pathway.

XC7201由176个胺基酸所组成，比对已知物种资料库后发现在原核真核菌中都有类似的序列，其功能被预测为3-hydroxyanthranilate 3，4-dioxygenase (3HAO)。3HAO是一种双氧化酵素，在生物体进行把Tryptophan转变成Quinolinic acid的生合成途径中最后一个反应的催化。

He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后，在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加，包括肾小球病和球外疾病等。