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Heat shock factor binding protein 1(HSBP1) is a nuclear-localized, novel, conserved, low molecular weight (00 residues) transcriptional factor, which may repress the activity of the heat shock factor 1 (HSF1) by binding HSF1 active trimerization domain.

热激因子结合蛋白1（heat shock factor binding protein 1， HSBP1）是一种新发现的高保守、低分子质量、定位于核中的一种转录因子，它可抑制HSF1的转录域活性，并协同HSP70负调控热激反应。

Expanding on our demonstration that acylated peptides derived from the large HBV envelope protein block virus entry in vitro, we show their applicability to prevent HBV or woolly monkey hepatitis B virus infection in vivo, using immunodeficient urokinase-type plasminogen activator mice repopulated with primary human or Tupaia belangeri hepatocytes.

已有的研究《Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans》（2007 Hepatology）表明来源于大蛋白的酰化多肽在体外能阻断病毒的进入。利用人源化肝脏或树鼩肝细胞的小鼠模型进行的新研究进一步证实，大蛋白的酰化多肽在防止HBV或者绒毛猴HBV体内感染中具有可行性。

A 46-year-old man presented with a gradually growing nodule on the left dorsal foot, which had been present for over 10 years. In the beginning, the lesion was treated as a keloid. Because of poor response to treatment, biopsy was arranged. Sections showed a dermal tumor composed of numerous foamy cells, hyalinized wiry collagen, spindle cells and entrapped collagen. The foamy cells were positive for KP1(CD68) and negative for S-100 protein and HMB-45. The histological and immunohistochemical results were consistent with the diagnosis of lipidized fibrous histiocytoma.

一位46岁男性从十年前开始於左足背上出现一个逐渐长大之结节，一开始被当作蟹足肿给予治疗，因为对治疗的反应不好，故安排了切片检查，病理显示一个由大量泡沫状细胞，坚硬而透明之胶原纤维，梭状细胞，胶原纤维束所构成的真皮肿瘤，免疫组织化学染色显示KP1(CD68)阳性，S-100 protein与HMB45阴性，综合病理与免疫组织化学染色结果，诊断为脂肪性纤维组织细胞瘤。

Kelch-like ECH-associated protein-1 (Keap1) normally sequesters Nrf2 in the cytoplasm in association with the actin cytoskeleton, but upon oxidation of cysteine residues Nrf2 dissociates from Keap1, translocates to the nucleus and binds to ARE sequences leading to transcriptional activation of antioxidant and phase II detoxifying genes.

在正常情况下，Kelch样环氧氯丙烷相关蛋白-1 (Kelch-like ECH-associated protein-1， Keap1)可将Nrf2与肌动蛋白细胞骨架一起收集在细胞质内，但是在半胱氨酸残基发生氧化的情况下，Nrf2和Keap1脱离，进入细胞核并与ARE结合，从而激活多种抗氧化基因和II相解毒基因的转录。

Kelch-like ECH-associated protein-1 (Keap1) normally sequesters Nrf2 in the cytoplasm in association with the actin cytoskeleton, but upon oxidation of cysteine residues Nrf2 dissociates from Keap1, translocates to the nucleus and binds to ARE sequences leading to transcriptional activation of antioxidant and phase Ⅱ detoxifying genes.

在正常情况下，Kelch样环氧氯丙烷相关蛋白－1(Kelch-like ECH-associated protein-1， Keap1)与Nrf2耦联，并与肌动蛋白细胞骨架结合被锚定于胞浆，但是在半胱氨酸残基发生氧化的情况下，Nrf2和Keap1解耦联，进入细胞核并与ARE结合，从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。

The result indicated that PBP1 was not expressed in stems, leaves and flowers, but specially expressed in root. 4. The protein in Brassica napus homologous to PBP1 was found through amino acid sequence blast and the interaction with BNP23 was identified by Yeast two hybrids assay.

通过同源比对找到与拟南芥PBP1有较高同源性的油菜的黑芥子酶结合蛋白(Myrosase binding protein 6，MBP6)，再次采用酵母双杂交验证它们的相互作用，结果显示MBP6与BNP23之间也存在相互作用； 5。

Objective To explore the relationship between heart-type fatty acid-binding protein levels and the severity of the affected coronary artery in acute coronary syndrome and to analyze the relevant reasons.

目的：探讨心型脂肪酸结合蛋白（heart-type fatty acid-binding protein，H-FABP）与近期发作急性冠脉综合征的患者冠脉病变严重程度的相关性及原因。

Objective To investigate the changes and the significance of the expression of Huntingtin-associated protein 1 （HAP1） in the adrenals of rats with to chronic multiple stress.

目的 探讨慢性复合应激大鼠肾上腺髓质细胞亨廷顿蛋白相关蛋白1（Huntingtin-associated protein 1，HAP-1）表达的变化及其意义。

The beat shock protein is produced by stress factors, and it can produce a aeries of corresponding physiological reactions to slow down the cell damage.

热休克蛋白(Heat Shock Protein， HSP)是生物体在受热或其他不利环境因素刺激下应激合成的一组特殊蛋白质。

Methods Ten mature Wistar rats were divided into normal control group (5 rats) and adenovirus (E1, E3-Deleted and carried math1 and enhanced green fluorescent protein report gene, Ad-Math1-EGFP) scala vestibuli transfer group (5 rats). Right ears of the Ad-Math1-EGFP transfering group rats were deliveried 5μl Ad-Math1-EGFP (physical tite 2.1×10^11v.p./ml) into cochleas through the way of drilling scala vestibuli of cochlear basal turn. As a control, the normal group received nothing to inner ear. In order to estimate functional condition of vestibule and cochlea, the click-evoked potentials on the surface of the cervical dura mater, auditory brain stem response and swimming time were recorded in all rats at 7 days after treatment, and then histologic and morphologic observation were carried out after animals were sacrificed. Results All animals' morphologic observation showed that inner ear hair cells were normal after transfer.

将10只成年Wistar大鼠分为正常对照组和缺失E1、E3基因片段且构建有Math1基因和绿色荧光蛋白报告基因的复制缺陷型腺病毒(adenovirus-Math1-enhanced green fluorescence protein， Ad-Math1-EGFP)前庭阶导入组，每组5只，实验组大鼠在右耳通过耳蜗底回前庭阶打孔的方法导入物理滴度为2.1×10^11v.p/ml的上述腺病毒5μl，对照组大鼠不做任何处理。7天后对动物进行颈髓硬膜外短声诱发电位(click-evoked potentials on the surface of the cervical dura mater， CDM-CEP)、听性脑干反应阈值检测和游泳试验，评价前庭和耳蜗功能，然后将动物处死进行组织形态学观察。

He knows that he's one of the mostdominant players in the NBA right now.

我知道他现在是联盟里最有统治力的球员之一了。

Using analysis method of BCG , the dissertation analyzed the management of voluntary service organizations .

利用BCG分析方法对我国的志愿服务组织管理进行了分析。