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Besides, HIF-1 can quickly induce a lot of expressions and the adjustment of anoxia-induced genes, so as to enhance the hypoxia-induced genetic transcription and increase the expressions, and engender physiological effects, such as adjusting the transcription of EPO genes to increase their production, thereby the red blood cells quantity is enlarged, which strengthens the ability of oxygen transportation and mitigates anoxia; adjusting VEGF genetic transcription to engender more blood capillaries, consequently the transportation and supply of oxygen and substance of energy source are strengthened; adjusting the glycolytic enzyme to enhance glycolysis ability under anoxemia condition and increase energy supply; functioning on HO-1 genes in vascular smooth muscle cells to produce HO-1, which can engender NO and CO as pneumatic signal molecules to activate the guanylate cyclases, thus CGMP level is improved to make the vascular smooth muscles chalasia, to restrain platelet agglutination, so that theblood flow and vascular permeability are increased, and the anoxic tissues obtain ample oxygen supply, etc..

在低氧环境中,HIF-1可以被很快诱导大量表达并介导低氧诱导基因的调控,使低氧诱导基因转录增强,表达产物增多,产生生理效应。

Methods:To produce antihuman DR5 monoclonal antibody(mDRA6) by immunizing BALB/c mice using DR5 protein. The change of DR5 expression after DDPtreated on HL60 cells was detected by FACS. Morphologic changes of HL60 cells were observed under fluorencence microscope. Cytotoxic and apoptotic effects of mDRA6 and DDP on HL60 cells were measured by MTT analysis. DNA fragmentation was detected by agarose gel electrophoresis.

DR5蛋白免疫BALB/c小鼠,融合筛选抗DR5杂交瘤细胞,制备抗DR5单抗——mDRA6;流式细胞术测定顺铂对HL60细胞表面DR5表达及细胞凋亡率;荧光显微镜下观察mDRA6与顺铂协同作用下HL60细胞形态变化;MTT法测定不同浓度的顺铂与mDRA6对HL60细胞存活的影响;琼脂糖凝胶电泳检测mDRA6与顺铂联合对HL60细胞DNA片段化的影响。

The results indicate that the effect of alloying elements V and Cr on mechanical properties at room-temperature, creep behavior and microstructures are similar. With increasing contents of V and Cr, their mechanical properties produce little change, the creep resistant property decreases and microstructure grows, which is mainly due to their characteristics of β-stability element and smaller atomic radius compared with Ti. On the contrary, the effects of V and Cr on the thermal stability are quite different. With increasing V content or decreasing Cr content the thermal stability for the alloy becomes better, which may be due to the different solution characteristics of V and Cr element in titanium alloy that V belongs to isomorphous β-stability element and Cr belongs to eutectoid β-stability element.

结果表明:合金元素V和Cr对Ti40合金室温力学性能、蠕变行为和组织的影响具有相似性,即随V和Cr含量的降低,合金室温综合力学性能变化不明显、抗蠕变能力减弱、组织粗化:这与V和Cr同属于β稳定元素、且原子半径都小于Ti原子有关;而V和Cr对于热稳定性能的影响则完全相反,V含量的增加或Cr含量的降低含金热稳定性能优化,其主要原因可能与V属于同品型β稳定元素而Cr属于共析型β稳定元素有关。

Changes in the vertical distance produce different effects of stress on edentulous jaw under the same load.

在同等载荷情况下,垂直距离的改变对无牙颌各区域产生不同的应力效果。

Three species of macrophyte (Elodea nuttalli, Vallinmeria spiralis, Alterranthera philoxerides), which are widely distributed in water environments, were used to perform solid-state fermentation to produce crude proteins. The effects of single-strain fermentation and mixed-strains fermentation of aquatic macrophyte on yields of their crude proteins and cellulase activities were analyzed.

采用微生物固体发酵技术对伊乐藻、苦草和喜旱莲子草3种高等水生植物进行单细胞蛋白生产的研究,分析单一菌种和混合菌种发酵过程中水生植物粗蛋白含量和纤维素酶活的变化过程。

With the investigation of the domestic and foreign literature systematically, the bases on the domestic and foreign present research and the comprehensive utilizations of the various knowledge of fluid mechanics in porous medium, reservoir engineering, mathematical physics, perforation completion, numerical simulation and so on, this article takes numerical simulation of gas reservoir of water solubility as the research aim which has completed following research works and obtained the corresponding research results: it analyzes the nature of the Water-soluble gas and formation water as well as the influent factors of the solubility through the study of massive materials; It establishes mathematical models three-dimension, the dual medium, the gas-water phase through the way of finite difference in the migration of water-soluble gas, which describes the entire process of release, migration and production in formation, where it considered the problems of variable bubble point; According to the numerical models of gas reservoir of water solubility it provides solution procedure that based on black oil model; It discovers that there will obtain the good effects in the lowly speed of development through simulation; the reinjection of formation water may largely enhance the produce degree of water-soluble gas when we consider reinjection in simulator; It considered the influence of perforated completion on development so as to increase the simulator"s versatility, It discovers that the simulator may reflect the conditions of development when we exanimate he simulator"s reliability with the empirical datum.

本文以水溶性气藏数值模拟研究为研究目标,在系统调研国内外文献、深入分析国内外研究现状的基础上,综合利用渗流力学、油气藏工程、数学物理方法、射孔完井以及数值模拟理论等多方面的知识,完成了以下研究工作并取得相应的研究成果;①通过对大量的资料调研,分析了水溶气、地层水性质、储层地质性质以及影响气体在水中溶解度的因素。②考虑到由于高压产生的大量水力裂缝,采用有限差分方法建立水溶气运移的三维、双重介质、气-水两相全隐式数学模型,该模型描述了水溶气在地层中的释放、运移和采出的整个过程。③在原有黑油模型的基础上,根据水溶性气藏数值模型编制了该数值模型的求解程序,该程序可以求解单重、双重介质两种情况。④通过模拟不同开采速度对水溶气开发效果的影响,发现开采速度较慢的时候可以取得较好的开采效果。⑤在模拟器中考虑了注水对水溶性气藏开发的影响,地层水回注可以大幅度提高水溶气的采出程度。⑥为增加模拟器的通用性,在模拟器中考虑了射孔完井方式对开采的影响。⑦检验模拟器计算的可靠性,发现在使用实验数据对水溶性气藏进行模拟时,模拟器可以很好的反映气藏开发的状态。

The results of the experiment had proved that propofol could produce favorable effects in sedation, hypnogenesis and propofol had a slight influence on analgesia, and that propofol had the characteristics of antivomit and antioxidation.

试验证实异丙酚具有良好的镇静、催眠和轻度的镇痛作用,并且具有抗呕吐、抗氧化的特性。

You may be the poorest man on the continent, and be deeply in debt; you may have neither friends, influence, nor resources; but if you begin to do things in this way, you must infallibly begin to get rich, for like causes must produce like effects.

也许你目前是全国最穷的人,而且还负债累累,也许你没有朋友、没有影响力、也没有任何资源;但是,因为同样的「因」必定会产生同样的「果」,所以只要你开始依照这种方法做事,就一定可以致富。

Structural thinking is the comprehensive consideration in a compose's mind when he is composing a musical piece, it contains the choices of the ways in which the music will develop and the decision on the form in which the piece will be. The structural thinking should transform into corresponding techniques and produce coincident sound effects.

综观利盖蒂的创作,可以发现他的作品即具有在结构的形成过程与结果上常常"出入意料"的处理,但又总是充满着朴素的艺术价值,即既能表现出在乐曲的组织过程和结构形式上的精雕细琢、又能表达出"一目了然"的情感诉求,更为重要的是其音响虽常使人们的听觉神经感到刺激,但却经得起反复聆听。

With the isolated and purified PSP as test materials, the chemical model systems were used to produce and OH. resp. And the scavenging capability of PSP on free radicals, its inhibition effect on pyrogallol autoxidation and the effects of PSP on SOD activity and MDA content in tumor-bearing mice were studied.

方法]以已分离提纯的甘薯多糖为试验材料,利用分别产生氧自由基O2(上标-和羟自由基的化学模型体系,研究甘薯多糖清除舟自由基能力及其对邻苯三酚自氧化的抑制作用和甘薯多糖对荷瘤小鼠SOD活性和丙二醛含量的影响。

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He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后,在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加,包括肾小球病和球外疾病等。

Pagans and partygoers greeted the summer solstice at the ancient stone circle of Stonehenge.

异教徒和社交聚会常客在史前巨石柱的古老的石圈附近庆祝夏至。