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In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

Results of animal experiment showed different changes of cholecystokinin and somatostatin in central, peripheral and regional were the main pathologic factor to causing spleen asthenia in the animal model of liver depression and spleen asthenia, and change of corticotropin releasing factor was the main factor to inducing liver depression.

动物实验结果表明在肝郁脾虚的复合模型中，引起脾虚的主要原因是CCK、SS在中枢、外周、局部的不同含量变化，而CRF的含量改变是肝郁的主要环节。

Cholecystokinin is a brain-gut peptide with broad biological activities. It is one of the main regulating hormones in the digestive system, and it plays an important physiological role in the central and peripheral nervous system as a neurotransmitter or a neuromodulator.

胆囊收缩素(cholecystokinin， CCK)是一种具有广泛生物学活性的脑肠肽，既是胃肠道主要调节激素之一，还广泛存在于中枢及外周神经系统中以神经递质或神经调质的形式发挥重要的生理作用。

The results indicated that the pesticide could be distributed through the body and cumulated in peripheral compartment relatively,but it could be eliminated rapidly.With parameters such as t1/2α valued 3.40min,t1/2β 59.03min and Cl 0.018ml·min-1,Its metabolism followed two-compartment open model after administration of 10 mg/kg.It was primary distributed to blood-riched organs and fat tissues and ready to be biotransformed.The metabolic product were detected in choler,which had stronger polarity with retention time 4.25min;and no parent compound was found in both urine and faeces.Key words: Toxicokinetics;Fenamithion;Organophosphorus pesticide

结果显示：螨胺磷在体内全身分布，并有周室富集，消除较快，在10mg/kg静脉注射呈二室模型，t1/2α为3.40min，t1／2β为59.03min，全身清除率Cl0.018ml·min-1；螨胺磷主要分布于血流量大的器官及脂肪组织；螨胺磷在体内不稳定，能被肝脏代谢转化成极性更高的化合物后经由胆汁排出，该成分可在同样的色谱条件下被分离，峰保留时间4.25min；粪尿中均未检出原药。

Radiologically, the lesion was well circumscribed and showed prominent peripheral calcification, consistent with chondroma.

放射学检查示病灶边界清楚，周围钙化，符合软骨瘤。

Objective: To observe the effect of melatonin on frequency of sister chromatid exchange and cell proliferation kenitics in lymphocytes from human peripheral blood in vitro.

目的：观察褪黑素对体外培养人外周血淋巴细胞的姐妹染色单体交换和细胞增殖动力学的影响。

An increased incidence of sister chromatid exchanges in peripheral lymphocytes of operating room personnel exposed to waste anesthetic gases has been reported.

已有报道，在暴露于麻醉性气体的手术室工作人员中，外周淋巴细胞姐妹染色体交换的发生率有所上升。

Methods: Peripheral blood lymphocytes from 30 women of childbearing age working with VDTs were cultured and conducted sister chromatid exchange and micronucleus analysis.

随机选择VDT作业及对照组的育龄妇女各30例，对其外周血淋巴细胞分别按姐妹染色单体互换检测方法及微核检测方法进行培养、检测。

Objective To study sister chromatid exchange fre quency in maternal peripheral lymphocytes and umbilical blood of pregnant women. It is objective to study causes and best assay about PIH.

目的 观察妊娠高血压综合征孕妇外周血及其脐血姐妹染色单体互换频率，探讨PIH的病因以提高PIH的检测水平。

For example, chrysotile fibres have been shown to depress the in vitro proliferation of phytohemagglutinin-stimulated peripheral blood lymphocytes, suppress natural killer cell lysis and significantly reduce lymphokine-activated killer cell viability and recovery.

例如，温石棉纤维已显示出抑制增殖的植物血凝素刺激的外周血淋巴细胞，抑制自然杀伤细胞溶解，并大大减少淋巴因子激活的杀伤细胞的活力和恢复。

As a dominant party,CPC government should play a guardian,supervisee and guarantee role to overcome all the difficulties in the development of charitable cause and bring it into full play in the establishment of harmonious society on policies and regulations basis.

在中国共产党的文献中第一次把发展慈善事业提到&最广泛最充分地调动一切积极因素，不断提高构建社会主义和谐社会的能力&的高度来认识。近年来，社会学界对慈善事业的理论专著发表较多，有鉴于此，笔者不揣浅陋，谈谈自己的认识和见解。

Flow through the land, the land of the scale of operation allows the effectiveness of the land may be raised.

通过土地的流转，土地的规模经营可以让土地的效益得到提升。