查询词典 oncogenes

This means that chemotherapy that targets oncogenes is not going to be effectie, says Loeb.

Leob说"这就是说针对癌基因的化疗并不是有效。"

Methylation is negative correlation with genetic transcription , and the mechanism is probably as follows : directly interfere the combination of specific transcripton and recognition site of each promoter ; mediated transcription inhibition by change the construction of chromatin; induced gene silencing by combination of methylation site and transcription inhibition. P16 gene is also called multiple tumor supresser gene , which is the best easily to methylate in the anti-oncogenes. P16 gene locates in 9p21 of mankind-chromatosome , and it's total length is 8.5kb .

甲基化与基因转录呈负相关，其机制可能是[3]：直接干扰特异的转录子和各自启动子识别位点的结合；通过改变染色质结构，介导转录抑制；甲基化DNA位点直接与转录抑制子结合，诱导基因沉默。p16基因又称为多肿瘤抑制基因( multiple tumor suppressor 1 ，MTS1) [4] ，是肺癌中最易发生甲基化的抑癌基因，该基因位于人类染色体9p21上，全长8.5kb ，由两个内含子和三个外显子组成。

AIM: To detect the expressions of HER-2/neu (c-erbB-2) and Ras oncogenes in cervical carcinoma,and to evaluate the roles of HER-2/neu and Ras in the genesis and development of cervix squamous cell carcinoma and adenocarci- noma.

目的研究HER-2/neu(c-erbB-2)和Ras癌基因在宫颈腺癌和鳞癌中的表达及意义，探讨其在宫颈癌发生发展中的作用。

It has opened a new way for the diagnosis and therapy of tumours, and also estab- lished the foundation for the carcinogenic mechanism research. In order to study the altered molecular events during laryngeal car- cinogenesis and elucidat the role of oncogenes in laryngeal carci- noma, we examined the Ha-ras and c-myc gene mutation and amplification by the polymerase chain reaction and molecu- lar hybridization technigues respectivly.

癌基因的研究是当前肿瘤领域内的重大课题，正在基础理论和临床医学中进行广泛和深入的研究，癌基因的发现为肿瘤的诊断和治疗开辟了新的途径，同时也为人类开始从分子水平来回答细胞癌变的本质问题，最终认识癌变机制奠定了理论基础。

The journal publishes reviews covers the whole field of the biology and biochemistry of cancer, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signalling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design.

该杂志主要发表有关肿瘤生物学和生物化学的综述。其内容包括：致癌基因和肿瘤抑制基因，与生长有关的细胞周期控制的信号转导，致癌机理，细胞转化，免疫控制机理，人类癌症遗传学，细胞增殖的控制，组织发育的遗传和分子控制，合理的抗肿瘤药物设计等。

There are enormous oncogenes and suppressor genes involved in cancer.

有巨大的癌基因和抑癌基因的癌症有关。

Methods Systematic observations of clinical manifestations,hematopoietic function,chromosomal aberrations,immunologic neurological,endocrinological,reproductive functions,eye examination,asssay of HPRT gene mutation and detection of oncogenes were performed in the past six years.

持续6年对患者进行临床表现、造血功能、染色体畸变、免疫功能、神经系统、内分泌功能、生殖功能及眼晶体等检查和HPRT基因突变及某些癌基因检测。

Chinese patent medicine ; Zilongjin ; hexamethylene bisacetamid ; cell cycle ; oncogenes ; genes ; tumor suppressor

中成药；紫龙金；环六亚甲基二己酰胺；细胞周期；癌基因；基因；肿瘤抑制

Objective To investigate the effects of the Chinese drug Zilongjin and hexamethylene bisacetamid on expression of oncogenes(c-ras,c-myc),and tumorsuppressor genes(Rb,p53,p21)of MGc803 cell in cell cycle.

目的 探讨中药紫龙金与环六亚甲基二己酰胺对人胃癌MGc80 3不同周期细胞癌基因c ras、c myc、抑癌基因Rb、p5 3、p2 1以及蛋白激酶PKC a基因表达的影响。方法采用Northernblot印迹法检测基因表达情况。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

Objective: To study the effect of polycythemia on blood oxygen saturation.

裴蕾目的：观察RBC剧增而引起的高粘血症对血氧饱和度的影响。

Based on SIMPLER algorithm in the curvilinear body-fitted coordinates, the calculations were performed for Pr=0.7, Re=10~1000 on non-orthogonal non-staggered grids which are generated by elliptic equation systems.

采用曲线坐标系下压力与速度耦合的SIMPLER算法，数值研究了周期性渐扩渐缩波纹通道内脉动流动与换热情况，流动Re数的范围为10~1000，Pr数为0.7。