查询词典 neuron

Objective: To observe and study the expression of microtube-associated protein tau in neuron-oriented differentiation for neural stem cells.

目的：研究神经干细胞向神经元定向分化过程中微管相关蛋白－tau的表达变化。

Key words Voltage-dependence miniature inhibitory postsynaptic current tectal neuron slice depolarization membrane potential Xenopus.

电压依赖性；微突触后电流；视顶盖神经元；脑片；去极化；膜电位；非洲爪蟾

Synaptic inputs activated repetitively within 20 ms before spiking of the tectal neuron become potentiated, whereas subthreshold inputs activated within 20 ms after spiking become depressed.

在四叠体突触尖波20ms前连续被激发的突触输入将造成突触电位化，然而在尖波产生的20ms后的小于临界输入将造成突触抑制。

Synaptic inputs activated repetitively within 20 ms before spiking of the tectal neuron become potentiated, whereas subthreshold inputs activated within 20 ms after spiking become depressed.

在四叠体突触尖波20ms前连续被激发的突触输入将造成突触电位化，然而在尖波产生的20ms后的小於临界输入将造成突触抑制。

To understand the basic properties, underlying mechanisms and functions of the short-term synaptic plasticity of thalamocortical visual pathway, we combined in vivo field potential recording, focal drug application technique and neuron models, to explore the short-tem synaptic plasticity of rat major thalamocortical visual pathway (from lateral geniculate nucleus to primary visual cortex) and extrageniculate pathway (from lateral posterior nucleus to primary visual cortex), as well as the role of short-term depression in the neuronal correlated firing detection.

我们结合在位场电位记录、局部加药和神经模型等方法，对不同刺激模式下大鼠丘脑皮层主要视觉通路（外侧膝状体到初级视皮层）和非主要视觉通路（膝体外通路：丘脑侧后核到初级视皮层）的短时程突触可塑性，以及短时程抑制作用对神经元同步活动检测的作用做了研究，试图了解视觉丘脑皮层突触传递短时程可塑性的基本特性、神经机制和功能。

These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer.

这是非同小可的，因为供体神经元只表达一个这样的蛋白，而不是完整的一套蛋白，说明大脑中所表达的嗅觉受体的多样性不是嗅觉神经元DNA中永久排列的结果。

Results OECs showed bipolar or tripolar after 6-9 days of culture. Primary spinal cord neurons were round and bigger, and neuron axons grew significantly and showed bipolar after 5-7 days of culture.

结果 OECs 培养6～ 9 d 后，细胞多呈双极形或梭形；脊髓神经元胞体较大，多呈圆形，培养5～ 7 d 后，突起明显生长，多为双突起。

In order to further investigate the relationship of SP and ESCs, we design two level experiments —in vitro and in vivo. In vivo, firstly, We establish the nomal rat full-thickness wounds model, and employ integrin β1 keratin 19(K19)、 keratin 15(K15)、 Brdu as ESCs markers to conform the existence of ESCs in the granulation tissue of Group Capsaicin (rats were subcutaneously injected capsaicin pre-injury to damage sensory neuron and block the secretion of neuropeptides), Group Control, and Group SP (rats were injected SP in the wound postinjury). Secondly, as diabetic skin lacking of SP due to extensive pathological changes of sensory ending, we make a hypothesis:one of the main reason of unhealing wounds on diabetic patients could be insufficient SP which lead to fewer ESCs recruitment around wounds.

在此基础上，为进一步验证P物质促进表皮干细胞向肉芽组织中募集这一重要发现，本研究首先利用β1整合素、K19、K15等干细胞标记物以及干细胞慢周期性的特点，分别在体观察了正常皮肤伤口愈合过程中SP组、辣椒素组采用特异性感觉神经毒性药物辣椒素(capsaicin皮下预注射化学性除去感觉神经从而阻止神经肽分泌、对照组肉芽组织中表皮干细胞分布特点；其次，糖尿病患者皮肤存在周围末梢神经的损伤和神经肽含量的下降，这是否会导致糖尿病皮肤伤口创缘表皮干细胞募集不足，继发伤口难愈？

Electron-microscopic observation: In stroke-prone spontaneous hypertension group, electron density was found increased in necrotic neurons; moreover, some nuclear membrane lost double-layer structure with ridges broken, even reduced or disappeared, displaying vacuolated changes. In losartan 30 mg/ group and losartan 10 mg/ group, most of neurons displayed basically normal morphology, with neuron chromatin evenly distributed and nuclear envelops regular, but there were still some neurons that had dense chromatin, with ridges broken and reduced.

3组大鼠脑组织电镜观察：易感型自发性高血压组大鼠坏死神经元电子密度增高，有的核膜失去双层结构，嵴断裂、减少甚至消失，呈空泡样改变；氯沙坦30mg/组和氯沙坦10 mg/组大多数神经元染色质分布均匀，核膜规整，细胞形态基本正常；少数神经元核染色质较致密，部分嵴断裂、减少。

Anti-filament immunofluorescence indicated the distribution of primary vestibular neuron endings in vestibular sensory epithelium and the contacts between it and hair cells were normal.These results indicated that Smad4 conditional knockout mice were generated successfully, whose morphological and pathological changes in vestibulum auris internae were slightly.

该研究提示，软骨组织Smad4条件基因敲除小鼠动物模型造模成功；Smad4条件基因敲除小鼠的内耳前庭形态轮廓基本正常但细节上有一定程度的畸形，纯合子小鼠前庭末梢感受器病理改变轻微。

The teacher likes the honeymouthed little girl very much.

老师很喜欢这个嘴甜的小姑娘。

Mr. Notker Bien's interests are traveling, spending quality time with the family and long-distance-running.

诺特卡·柏恩先生热爱旅游，长跑，以及和家人一起共度美好时光。