查询词典 membered

Two ring structures(a five- membered ring and a six membered ring) were formed simultaneously.

并相应地形成了六元环和五元环结构。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

The temperature of the zeolite structure damage is at 1169℃.According to the sorption isotherms, hexane and methanol are adsorbed in the ten-membered ring channel. Methanol molecules can enter the small cage through the eight- membered ring window at high partial pressure. The adsorption of water correlates to Si-OH defect and concentration of cations in the zeolites.

吸附现象表明，正己烷和甲醇都被吸附于FER沸石的十元环主孔道中，分压较高时，甲醇可通过八元环进入小笼，而水的吸附性质则主要与各样品的Si-OH缺陷及骨架中的阳离子含量有关。

Methanol molecule participates in the proton transfer process, which takes place by a intermolecular six-membered proton-transfer transition state structure instead of the intramolecular four- membered. Consequently, the activation energy of the proton-transfer process is reduced greatly,resulting in the carbon-carbon bond formation process become the rate-determining step. The results are consistent with Aggarwal's the latest dynamics experiments.

CH3OH分子参与质子转移过程，使得原本通过四元环结构过渡态的质子转移过程通过六元环结构过渡态实现，从而极大地降低了质子转移过程的活化能，碳-碳键形成过程进而成为反应的速度控制步骤，研究结果与Aggarwal等的最新动力学研究成果相吻合。

In order to obtained the six-membered ring compound and a thorough assignment of the spectra, and further to prove that the six-membered ring compound was formed from the hydrogen transfer, the compound N-butyl-4-(N-methylphenylamino)-5-amino- 1, 8-naphthalimide 6 was designed to obtained with N-butyl-4-bromo-5-amino-1, 8-naphthalimide and N-methyl phenylamine as the starting material. However it was difficult to obtain the desired product as the different solvent giving the different products except the desired product.

为了能够得到六元环化合物作为定标的物质及其确切的谱图分析结果，并且为了进一步证明由五元环产物通过氢转移得到六元环产物的正确性，设计用N-丁基4-溴-5-氨基-1，8-萘酰亚胺与N-甲基苯胺反应生成N-丁基-4--5-氨基-1，8-萘酰亚胺6，结果发现这种方法很难实现，选择不同的溶剂会生成不同的产物，却都不是目标产物。

This dissertation is dedicated to investigate the pyrolysis of the fuel-bonded nitrogen model compounds,including five-membered ring nitrogen model compound pyrrole and the substituted six-membered ring nitrogen compound 4-methyl pyridine,with vacuum ultraviolet single-photon ionization combined with molecular beam mass spectrometry technique.

本论文利用同步辐射真空紫外单光子电离、分子束取样和反射式飞行时间质谱相结合的技术研究了含氮杂环模型化合物的热解，包括五元环含氮体系、六元环含氮体系和替代的六元环含氮体系(4-甲基吡啶)。

New ruthenium benzylidene complexes benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-diphenylphosphinoacetato] monochlororuthenium (46), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene][k~2-3-propionato]monochlororuthenium (47), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-2-benzonato]monochlororuthenium (48) featured five-membered, flexible six-membered and rigidsix-membered chelating rings respectively are prepared by reactions of complex 41 withcorresponding sodium phosphino-carboxylates. It is confirmed by X-ray crystallographicanalysis that the coordination geometries of complexes 46 and 47 are distorted squarepyramids with phosphino-carboxylate ligands chelating to ruthenium, and the coordinationbetween ruthenium and benzylidene ligands are strengthened.

用二苯基瞵乙酸盐、二苯基膦丙酸盐、二苯基膦苯甲酸盐与钌卡宾配合物41反应合成了三个新的钌卡宾配合物：含五元膦-氧螯合环的1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(46)、含六元柔性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(47)及含六元刚性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基]-苯亚甲基--一氯合钌(48)。X射线单晶衍射分析证明，配合物46、47都为变形的四方锥构型，膦-氧与钌形成螯合配位，其中苯亚甲基与钌的配位得以加强。

This invention pertains to compounds of Formula I, their N-oxides and suitable salts wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally including one or two ring members selected from the group consisting of C, SO or S2, each ring optionally substituted with from one to four R; each J is independently a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system, wherein each ring or ring system is optionally substituted with from one to four R; and R, R, R, R and n are as defined in the disclosure.

本发明涉及式I的化合物、其N-氧化物和适当盐，其中A是O或S；G是任选地包含一个或两个独立选自C、SO或S 2 的环成员的5-或6-员杂芳环或5-或6-员非芳族杂环，各环任选地被1-4个R 2 取代；各J独立地是苯环，5-或6-员杂芳环或芳族8-，9-或10-员稠合的碳二环或杂二环系，其中各环或环系任选地被1-4个R 3 取代；R 1 ，R 2 ，R 3 ，R 4 和n如说明书中定义。

From the potential energy profile, it can be predicted that, the dominant channel of this reaction consists of three steps: the two reactants first form a three-membered ring intermediate (INT1) through a barrier-free exothermic reaction of 19.2 kJ/mol; three-membered ring intermediate (INT1) isomerizes to a four-membered ring silylene(P2) via the transition state (TS2) with an energy barrier of 22.8 kJ/mol; four-membered ring silylene(P2) further reacts with ethene(R2) to form a silicic bis-heterocyclic compound (P3), which is also a barrier-free exothermic reaction of 132.2 kJ/mol.

用CCSD//MP2/6-31G*方法研究了单重态二甲基亚烷基硅烯与乙烯生成硅杂双环化合物环加成反应的机理，根据该反应的势能面可以预言，该反应的主反应通道有三步组成：第一步是两反应物（R1， R2）首先生成了一三元环中间体（INT1），它是一无势垒的放热反应，放出的能量为19.2 kJ/mol；第二步是三元环中间体(INT1)经过渡态TS2异构化为了四元环硅烯（P2），其势垒为22.8 kJ/mol；第三步是四元环硅烯（P2）进一步与乙烯(R2)反应生成了硅杂双环化合物（P3），该反应也是一无势垒的放热反应，放出的能量为132.2 kJ/mol。

The two competitive reactions both consist of two steps, two reactants firstly form a three-membered ring intermediate (INT1) and a twisted four-membered ring intermediate (INT2), respectively, both of which are barrier-free exothermic reactions of 41.5 kJ/mol and 72.3 kJ/mol; then INT1 isomerizes to a four-membered ring product (P1) via transition state (TS1), and INT2 results in the chlorine-transfer product (P2) via transition state (TS2), with the barriers of 2.9 kJ/mol and 0.3 kJ/mol, respectively.

INT1和INT2分别经过渡态TS1和TS2异构化为了四元环产物P1和生成了氯迁移产物P2，其势垒分别为2.9和0.3 kJ/mol。

The physiology of the skin machine body for the sake of the environment in the maintenance stability, but eject a body metabolism creation of metabolism thing BE'grease', summer perspire many various skin disease light or good, autumn perspire little metabolism thing metabolism don't go out, various skin disease made, this be the skin machine body of various burning disease.

皮肤机体的生理为了维持内环境稳定，而排出身体代谢产生的代谢物是'油泥'，夏天出汗多各种皮肤病就轻或好了，秋天出汗少代谢物代谢不出去，各种皮肤病就犯了，这就是皮肤机体的各种炎症。

If I had anything tender in me, I shot it dead.

如果我有什么招标的话，我枪死亡。