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The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法,研究丘脑网状核(nucleus reticularis thalami,RT)中γ-氨基丁酸(gamma-amino butyric acid ,GABA)能神经元、一氧化氮(nitrogen monoxidum,NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate,cAMP)及中缝背核(nucleus raphes dorsalis,DRN)至RT的5-羟色胺(5-hydroxytryptamine,5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP,5μg),注射当天睡眠时间略有减少,第二日睡眠时间显著减少,觉醒时间明显增多,第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后,与生理盐水组比较,睡眠时间增加,觉醒时间减少;而RT内微量注射L-谷氨酸(glutamic acid, L-Glu, 0.2μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline,BIC,1.0μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen,BAC,1.0μg)后,产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg,0.5μg)后,与生理盐水组对比,睡眠时间略有减少,但无显著性意义;而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside,SNP,0.2μg)后可明显增加觉醒时间,缩短睡眠时间;微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine,L-NNA,2.0μg)后,引起睡眠时间增多,觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用;RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后,与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠,其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate,MOR,1.0μg)后与生理盐水组对比,睡眠时间减少而觉醒时间增加; RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride,NAL,1.0μg)后与生理盐水组比较,睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后,与生理盐水组对比,原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较,睡眠时间增多而觉醒时间减少;RT内微量注射亚甲蓝(methylene blue,MB,1.0μg)后,与NS组比较,睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 0.2μg)比较,睡眠时间减少,觉醒时间增多;大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射二甲基麦角新碱(methysergide, MS, 1.0μg )后,与对照组(DRN注射L-Glu 0.2μg,双侧RT注射NS 1.0μg)比较,睡眠时间增多,觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine,PCPA,10μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 1.0μg)比较,睡眠时间增多,觉醒时间减少;大鼠DRN内微量注射PCPA(10μg),产生睡眠增多效应后,在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan , 5-HTP, 1.0μg )后,与对照组(DRN注射PCPA 10μg,双侧RT注射NS 1.0μg)比较,睡眠时间减少,觉醒时间增多。

The thesis contains five chapters. The first chapter summarizes the development and research of switched reluctance drive, discusses the main research direction, and explains the main work in this paper. In chapter 2, hardware system which includes the design of power converter and various control circuit is discussed. TMS320LF2407 DSP is used to design the hardware circuits of SRM control system, and design details including the current detection, position sensing, fault protection, speed detecting, keyboard and display etc. are provided. Because of the full use of the abundant peripheral resources of DSP, it comes to the aim simplifying the circuit structure and heightening the reliability. In chapter 3, the application of neural network on SRM control system is introduced, a new the application of neural network and the method of sampling is proposed and a simulation system based on Matlab/Simulink is established. Chapter 4 discusses the routine designing issue. Because the modularized programming method is adopted, and multi-interrupt processing technique is used, operation efficiency of the control software is highly raised. At last, the foregoing SRM control system is tested. Speed adjustment is realized, and other targets on the research and design of SRM control system are reached, which establishes a good foundation for further research.

本文共分五章,第一章概述了开关磁阻电机调速系统(Switched Reluctance Drive,简称SRD)及其发展和研究现状,论述了其主要研究方向,并说明了本文的主要工作;接下来的一章主要讨论了SRM的硬件系统,主要包括功率变换器的设计和各种控制电路的设计,本文以TMS320LF2407为核心设计了开关磁阻电机控制系统硬件电路,给出了包括电流检测、位置检测、故障保护、测速电路及键盘和显示电路等部分电路的详细设计,充分利用了DSP的丰富外设资源,达到了简化电路结构、提高运行可靠性的目的;第三章介绍了人工神经网络在开关磁阻电机控制系统中的应用,提出了一种新的应用方式(利用GPFN神经网络调节PI参数)以及如何采取样本,搭建了基于Matlab/Simulink的仿真系统;在第四章中,讨论了开关磁阻电机控制软件的设计,采用模块化编程方法,采用基于多中断的控制程序,提高了控制软件的效率;最后,对所设计的开关磁阻电机控制系统进行了实验,实现了电机调速,达到了开关磁阻电机控制系统研究和设计的预期目标,为更近一步研究打下了基础。

It becomes more difficult to manage, integrate and share the control system real-time data when we set up the industrial real-time database because of complicated affair between every department and isomeric character of the system. A three-level-structure model and the method to establish database is provided based on CORBA criterion with its character of being regardless of programming languages, hardware platform and network protocol . A universal real-time database faces multi-system is also set up by learning the distributed criterion, it can realize the request broker , and the application software can visit the database pellucidly ; Thus the power station simulation model can be linked with the control system such as infi90 , ovation and be made use of the control object , a closed simulation and control experiment system is set up. Further more we can build an integrate automatic experiment platform from the simulation object of power plant to the process control and the to SIS. Li Ming(Control Theory and Control Engineering)Directed by associate prof. Lin Yongjun

在创建工控领域实时数据库时,企业各部门间的复杂事务及内部异构性给实时数据的管理、集成和共享带来了一定的困难,根据CORBA规范具有语言无关性、平台无关性和网络协议无关性的特点提出基于分布式计算规范CORBA的三层体系结构模型及建立与维护实时数据库的方法和途径;通过CORBA规范建立面向多个分散控制系统的通用实时数据库,实现数据访问代理,使应用软件可以透明地对实时数据库进行访问、存取、管理;将Infi90、Ovation分散控制系统与火电厂仿真机模型进行有效的互连,以全物理过程仿真数学模型为对象,构建了闭环控制仿真实验研究系统,实现数据的高效连通及管理;进而通过基于CORBA的实时数据库构建一个从火电厂仿真机对象到过程控制设备再到SIS系统的综合自动化试验平台。

The main content of this thesis is as follows: 1The structures of EPS are analyzed. The main components of EPS are introduced in detail. Then the distributed torque in EPS is analyzed and the control system model is set up. 2Three control modes are discussed and the control strategy of EPS is studied in detail. Three principal modules in the control strategy are discussed—the predicted module which predicts motor rotational speed and steering rotational speed, the power-assistant module and the return control module. 3The assistant torque curves of the motor are designed by using the B-spline, so that any kind of custom-built assistant torque curves can be designed according to different kinds of automobiles. 4The hardware frame of EPS is studied. The developed controller based on 8-bit MCU MC68HC908MR8 is introduced and many related circuit units are designed, including the control circuit, the driver control circuit and so on. The software structure is discussed, then the steering control program flowchart is given.

本文的主要工作有: 1分析了EPS 的总体构成,对EPS 的各个部件作了详细的介绍,并在此基础上分析了EPS 的受力情况,建立了控制系统模型,并研究了EPS 的安全性能; 2讨论了EPS 的三种控制方式,提出了控制策略,并讨论了其中三个关键模块的作用:预估模块包括对电机转速和方向盘角速度的预估,助力控制模块以及回正模块; 3用B 样条插值方法进行EPS 助力曲线的设计,可按照用户的要求设计任意形状的助力曲线,以满足不同车型和不同用户的要求; 4研究了控制系统的硬件结构,以MC68HC908MR8 为核心设计了控制器,详细讨论了控制器的控制电路、驱动电路等;设计了控制系统的软件,给出了控制程序流程图,并对要点进行了详细的说明。

The objectives of this paper were to investigate the simulation and design of continuous multiple-station rolling forming process for a U-Section Steel Bar by CAE software-DEFORMTM Due to the limitation of elements number using a short strip 120mm went through all the stations to simulate the real continuous rolling forming on factory The roller gap was fixed as 0 30mm roll speed was 20 rad/sec and progressive angles were all equal for each rolling process which were the formed angle divided by by the number of station Three rolling processes were selected with 6 9 and 12 stations respectively During simulation processes two cases occurred Case A the strip was through a single station Case B the strip across two stations Because the strip laterals side was stretched and twisted during the process The model of case B closer to the practical process than case A and the calculated stress and strain on the tip of U section for case A were lower than these for case B by up to 15% From the result of case B for each process the stress for 12-station process was smallest 9-station process second and 6-station process next Because less-station can save larger cost and forming time but the bigger stress and strain for 6-station caused wrinkles on lateral sides not found on 9-station and 12-station Therefore 9-station process was a more suitable design than 12-station process smaller stretched and twisted and stress The progressive angles for 12-station was 7 5?

本文主要是以DEFORMTM有限元素软体模拟U型钢片连续道次成型与单一道次成型以确认单一道次模拟的是否可取代连续道次模拟之研究。因DEFORMTM 软体对於网格元素上的限制故使用较短素材120mm通过所有的成型站以模拟工厂实际连续成形方法。辊轮间隙固定为0 3mm;辊轮转速为20 rad/sec;弯曲角度的方法为将成型角度平均除以成型站数。有三种辊轮成型方式被选择分别为6站,9站,与12站。在模拟的过程中有两种现象会产生 Case A,素材通过单一成型站。Case B,素材会通过两个成型站。因为在模拟过程中素材的两端会有拉应力与扭力。Case B的模拟比Case A像实际的制程,并计算应力与应变在U型断面的Tip部中可发现Case A比Case B低约15%。从Case B的每站的结果可以得知,12站的成型应力最小,9站次之,6站最后。

Design the hardware block diagram that the main foundation closed the control system of the ring in the hardware of the system, and export the hardware that the passway need to choose to the input channel.

在系统的硬件设计主要根据闭环控制系统的硬件框图,对输入通道和输出通道所需的硬件进行选择。

Integrating trellis-coded modulation with threaded algebraic space–time block code, trellis-coded modulation space-time block code is presented, which has the advantage of full-diversity and small detection delay. Based on TCM pre-processing, the minimum distance between different codeword matrixes of the TCMST block code is maximized, so the average bit error rate of the TCMST block code is lower than that of the TAST block code at the same signal noise ratio.

TCMST分组码具有满发送分集度和检测延迟小等优点;由于采用了TCM预处理,使得不同TCMST分组码码字矩阵间的最小距离达到了最大化,因此在相同信噪比情况下,TCMST分组码具有比TAST分组码更低的平均误比特率。

Traveling Block - The block and tackle which is rigged with the crown block by multiples of drilling line strung between the crown block and the traveling block.

游动滑车:通过排列穿过天车和游动滑车的多股钻井绳和天车装配在一起的滑轮及装备。

From the perspective of geologic evolution, this paper discusses the conformation features of fault block, emphatically demonstrates the closure property of the margin of complex fault block and the controlling of the fault block internal structure on accumulation of CBM, and points out that the synclinal and synclinorial areas of thrust fault block and structurally triangle fault block areas would be favorable for CBM occurrence.

本文从构造演化出发,讨论了区内复杂断块的形态类型特征,着重论述了复杂断块体边界断裂的封闭性以及断块体内部构造配置对煤层气成藏的控制作用。分析得出逆冲断块的向斜、复向斜区域和构造三角断块区是煤层气成藏的有利区块。

But thermal expansion secant coefficient for concrete block is 10×10~(-6), it is doubleness of clay block., so concrete block is sensitive than clay block and is easy to bring cracks. Concrete block has been utilized as a kind of wall material for more than 30 years in China.

但是混凝土砌块砌体的线膨胀系数为10×10~(-6),比砖砌体的大一倍,因此,混凝土砌块砌体对温度的敏感性比砖砌体高,更容易因温度变形引起裂缝。

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推荐网络例句

The statistical analysis of this large set of mutations has led us to propose a diagnostic strategy that should help with the molecular work-up of optic neuropathies.

这一大系列基因突变的统计学分析引导我们提出一个诊断策略,可以帮助我们对视神经病变进行分子学的诊断检查。

The results show that the pipe grouting changes the mechanical parameters of surrounding rocks to achieve the security of engineering objectives by reinforcing surrounding rocks and bolcking the water.

研究表明:小导管注浆一方面改变了围岩的力学参数,另一方面利用浆液的固结特性可以实现堵水和加固围岩的工程目标,使隧道在开挖过程中的安全得到保障。

She did not make it through many auditions with many people telling her to give up but she didn't.

尽管经历了许多次试唱机会,她的梦想纷纷落空。期间很多人都劝她还是放弃巴,但她仍然守护者自己的梦。