查询词典 growth cone

The three main cytoskeleton elements in the nerve growth cone are microtubule, actin microfilament, as well as actomyosin.

微管通常只延伸到生长锥的基部，对神经纤维起稳定作用。

In many cases, ephrins act as negative regulators that stimulate growth cone collapse and inhibit neurite outgrowth.

在许多例子中，ephrin对於神经的发育扮演著负向的调控者，它们能够刺激神经生长锥的萎缩而抑制神经纤维的生长。

In the center photo, the regeneration gene has been over-activated, so it grows upward with a normal growth cone and not too many branches, allowing it to eventually reach the major nerve.

中间图片中再生基因被过度激活，其向上生长时带有一个正常的"生长锥"，且分支也不太多，最终它将到达顶部的主神经。

Low concentration ryanodine can mimic BDNF to induce growth cone attraction and high dose ryanodine gradient is repulsive to the growth cone.

结果发现，表达DN-Cdc42或CA-Cdc42 能够阻断BDNF 及低浓度ryanodine的浓度梯度对轴突生长锥的化学吸引作用。

Furthermore, we found that the Sema3F-triggered growth cone attraction was abolished by inhibition of the cGMP signaling pathway but not by inhibition of the cAMP signaling pathway, and the attraction was suppressed when elevating the intracellular cGMP level.

而且，在组织块共培养中，分泌Sema3F的细胞团能使小脑颗粒细胞偏向它迁移。我们发现Sema3F的吸引性作用在cGMP信号通路被抑制时受阻断，在细胞内cGMP水平增加时被削弱。

A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.

一个在UNC5 和DCC家族受体细胞质领域间的配体门控联合把netrin诱导的发育锥体细胞吸引力转变为了排斥力〉《细胞》第97卷，(1999)： 927-41页。

Low concentration ryanodine can mimic BDNF to induce growth cone attraction and high dose ryanodine gradient is repulsive to the growth cone.

ryanodine 可以模拟 BDNF 的吸引作用。为进一步研究 Rho GTPases 在轴突转向中的作用，我们将 Cdc42及 RhoA 的显性失活突变基因(dominant negative， DN)及组成性激活突变基因（ constitutively active， CA ）注射到爪蟾胚胎2-4细胞期的一个细胞中，使它们在胚胎神经元中表达，并观察这些突变基因对 BDNF ， LPA ， ryonodine 诱导的轴突转向的不同影响，从而推测 Rho GTPases 是否直接参与并介导轴突导向。

The possible mechanism is that, when there is an asymmetry of RhoA activity in the growth cone, the filopodia at the lower RhoA activity side will extend faster then the other side because of lower inhibition or retraction, and hence the growth cone will turn towards this side.

可能的机制是，当生长锥内一侧的 RhoA 活性较另一侧高时，丝状伪足在 RhoA 活性低的一侧受到的抑制较弱，延伸更快，因此生长锥朝向该侧转向。

One simplified hypothesis is that, when the growth cone detected the directional signal, actin will polymerize asymmetrically in the growth cone, so that the filopodia and lamelipodia will extend preferentially to one side, microtubule will further follow and stabilize this growing direction.

一种假说认为，当轴突生长锥探测到方向性的信号时，生长锥内的 actin成分发生不对称聚合，filopodia及lamelipodia向一侧优先延伸，进而轴突内微管也朝同侧延伸，使生长方向进一步稳定下来。

Although we have not a tool to directly modulate the cellular Cdc42/Rac activity at present, nevertheless, from the abolish of BDNF-triggered attraction by either DN-Cdc42 and CA-Cdc42, we propose that an intracellular Cdc42 activity gradient may also be sufficient to determine the turning direction, say, filopodia extend preferentially at the higher Cdc42 activity side, and the growth cone turn towards this direction in the hence.

虽然我们目前还没有一个直接操纵细胞内 Cdc42或其下游分子活性的方法，但从 DN-Cdc42和 CA-Cdc42均阻断到 BDNF 和 ryanodine 的吸引作用来看，我们推测， Cdc42的活性梯度很可能也能够决定生长锥转动方向，即丝状伪足在 Cdc42活性高的一侧优先延伸，生长锥朝向该侧转动。

He is the most remarkable man that I have ever known.

他是我知道的人中最值得注意的人。

Increased appearance of lymphocele was noticed in patients with diabetic nephropathy, congenital malformations of the urinary tract, and inflammatory diseases, including glomerulopathy and extraglomerular ones, after high-voltage radiotherapy and after removal of the renal graft.

经过高压放射疗法和切除移植肾后，在糖尿病肾病患者、泌尿系统先天性畸形患者和炎症患者身上发现淋巴囊肿有所增加，包括肾小球病和球外疾病等。