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The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

In chapter 4, basing theories and methods of scientific visualization, and artificial neural network BP algorithm, we integrate the Visual C++, OpenGL graphics library and Excel VBA technique to develop the program of artificial neural network and to make the BP algorithm visually, this program works can be divided into four parts: Using C language to develop program about BP algorithm; Using Visual C++, develop the GUI Interface, make input parameter visually; Using OpenGL graphic technique to display the training sample point in three dimension; at last using Excel DDE technique display the error graphic tables in Excel system In chapter 5, on the view of engineering application, we establish new method of surface reconstruction basing artificial neural network, develop interface program between module and commercial CAD/CAM system, meantime deeply discuss some key problems, for example, setting up the base plane, using the API technique, cutting and editing surface boundary, and also discuss the more compliant problem: how to intersect surface, at end we finish the work of translation from our surface reconstruction module to commercial CAD/CAM system, then make reverse engineering system basing artificial neural network more useful.

第四章基于科学计算可视化理论，依据人工神经网络BP算法理论模型，综合Visual C++，OpenGL图形库以及Excel VBA等多项软件开发技术，编制了人工神经网络程序，实现了BP算法的可视化映射。具体工作分为四部分：利用C语言实现人工神经网络BP算法；利用VisualC++的GUI技术开发图形用户界面，实现参数设置可视化；利用OpenGL图形技术进行三维映射，显示学习样本及训练样本点；利用微软电子表格DDE动态数据交换技术，在Excel上动态显示学习误差曲线图。第五章从工程应用的角度出发，提出了一种新的基于人工神经网络算法的曲面裁剪重构方法，完成了曲面重建模块与通用CAD/CAM系统的接口设计工作，对其中的若干关键问题进行了深入讨论，例如基平面设定、API技术的应用、边界裁剪等问题，同时，对曲面计算中较为困难的曲面相交问题也进行的专门探讨，最终完成了曲面重建模块向CAD/CAM系统的数据传输工作，使人工神经网络逆向工程系统趋向实用。

Prospect future, super voice the wave spread the feeling machine conduct and actions a kind of new count for much and useful tool and will have very big development space in everyone's noodles, it wears the dynasty more high to position the direction development of the high accuracy to develop increasingly by satisfy of social need is basic such as the development trend of the sonar is:Develop to have higher fixed position accuracy of passive measure to be apart from sonar to carry out the demand of whole concealment attacks by satisfying weapon in water;Continue to develop the submarine of the adoption low frequency line table examination to drag the line array sonar, carry out super long range of passive probe into and identify;Develop the submarine sonar of the more suitable for neritic work, resolve the target in the neritic water to identify a problem especially;Lower a submarine strongly from the bad voice, the work environment of the improvement submarine sonar.

展望未来，超声波传感器作为一种新型的非常重要有用的工具在各方面都将有很大的发展空间，它将朝着更加高定位高精度的方向发展，以满足日益发展的社会需求，如声纳的发展趋势基本为：研制具有更高定位精度的被动测距声纳，以满足水中武器实施全隐蔽攻击的需要；继续发展采用低频线谱检测的潜艇拖曳线列阵声纳，实现超远程的被动探测和识别；研制更适合于浅海工作的潜艇声纳，特别是解决浅海水中目标识别问题；大力降低潜艇自噪声，改善潜艇声纳的工作环境。

Megaspore mother cell just enters leptotene as The meiosis of microspore mother cell develop into tetrads . The meiosis of megaspore mother cell develop into pachytene while that of microspores develop into a single nuclear adjacent to cell wall.

当白杨小孢子母细胞减数分裂至四分体时，大孢子母细胞开始进入减数分裂细线期；而当小孢子发育至单核靠边期上时，大孢子母细胞减数分裂达到粗线期。

Use the Marxist person harmonizes with nature to develop the thought to re- examine just modern mankind's civilization of be placed in the confused stage, the especially natural ecosystem environment was use by us a kind of way that depends on the excessiveness to consume the natural capital to seek the development, can get: Want the real realization Sustainable Development, can't develop the way to look for and can keep on to develop the mode from the economy alone, but must with the Marxism Sustainable Development thought for leading, carry out to develop completely.

用马克思主义人与自然和谐发展思想来重新审视正处于困惑阶段的现代人类文明，特别是自然生态环境被我们用一种依靠过度消耗自然资本来谋求发展的方式，就可以得出：要真正实现可持续发展，就不能单独从经济发展方式去寻求可持续发展模式，而必须以马克思主义可持续发展思想为指导，实现全面发展。

Though there is no unrealizable technical difficulty for FTTH, its success shall highlight the following aspects and integrate efforts to solve the key points: develop new device and kernel control chip adapting to features of FTTH, reduce the cost of optoelectronic devices and passive devices; develop low cost, easy installation indoor optical fiber, cable and linker as well as matching construction equipments and tools; develop high density, easy operation optical fiber distribution frame; and develop concentrated remote monitor, management techniques and systems.

FTTH技术是未来宽带接入的主要模式，从长远来看也是其他技术无法取代的，FTTH虽然没有技术上不可实现的难点，但要使FTTH走向成功，以下方面值得重视并应集中力量攻关：开发适应FTTH特点的新型器件和核心控制芯片，降低光电器件和无源器件的成本；开发低成本、易安装的室内光纤、光缆和连接器及相配合的施工仪器工具；开发高密度、易操作的光纤配线架；开发集中的远程监视和管理技术及系统等（178）。

Follow-up for 5 years is hit by result to 160 fat example crowd , 10 examples develop for blood sugar is damaged (IFG on an empty stomach, 6.2%), 28 examples develop for candy is able to bear amounts abnormal (IGT, 17.7%), 13 examples develop for 2 type glycuresis (T2DM, 8.12%), 79 examples develop for hypertension (HT, 49.4%).

结果 对160例肥胖人群5年的随访中，10例发展为空腹血糖受损（IFG，6.2%），28 例发展为糖耐量异常（IGT，17.7%），13例发展为2型糖尿病（T2DM，8.12%），79例发展为高血压病（HT，49.4%）。

Their life-long learning and developing is also improved. The conclusion of the study of the multi-dimensional design of primary school English assignments can be drawn as follows: 1.The assignments can develop students' language skills. 2.They can help develop students' multiple intelligences. 3.They can develop students' nonintellectual factors such as study habits, interests, emotion factors and so on. 4.They can develop students' abilities such as imagination, self-study ability, the faculty of memory and practice.

本研究的主要结论是：1）对小学英语拓展性作业进行多维化设计，可以拓展学生的语言技能2）对小学英语拓展性作业进行多维化设计，可以拓展学生的多元智能3）对小学英语拓展性作业进行多维化设计，可以拓展学生的非智力因素4）对小学英语拓展性作业进行多维化设计，可以拓展学生的各种能力。

First of all,it discussis develop background and synopsis of this system;then,it discussis three technologies of developing thods,namely,it involves in tway of SDLC,the way of Prorotype,the way of OO,and the way of th system;it elaborately expound technologies and appviation of Systems Analysis and System Design,especialy the commu between ement and Students by meas of C/S(Client/Server);it also discussis the question and the knowledge during develop this system;during develop this system, I understand the thinking and method of develop MIS.

全文共分为绪论、开发方法的选择、系统分析、系统设计、系统实施、结束语等六章。首先论述了该系统的开发背景和系统的简单介绍；然后，讨论了结构化生命周期法、原型法和面向对象这三种开发方法的技术，根据需要选择合适的开发方法；结合本系统详细阐述了系统分析、系统设计的技术及应用，尤其在机房管理人员和上机人员的交流方面采用了C/S结构进行解决；此文还论述了在开发过程中遇到的问题及学到的东西。

In our experiment, we found two abnormal phenotypes that one only the last three segments develop into pupa, but the other segments are still keep the larva characters; another sample has differently develop speed between abdomen and backside, which resulted in the back develop into pupa but the abdomen were still the larva characters. When we add Az in the feed of injected EcR-dsRNA samples, in the 13 live larvae we found that 6 have the abnormal proleg phenotypes.

在另一组注射EcR-dsRNA以后通过浸叶法添食不同浓度的印楝素，在10ppm处理组存活的13个个体中有6个出现特异表型，其中两个幼虫为不完全蜕皮，尾部体节无法蜕皮导致发育受阻；另外发现4个供试虫体发育至五龄时出现腹足缺失表型，其中有两个是腹足几乎全部缺失，腹足应该生长的部位只有少数几个突起，没有发育成形的腹足；一个出现左侧腹足完全缺失，右侧第二腹足缺失表型；另一个个体只缺失了左侧最后一个腹足。

A backer of an Afghan law that critics say legalizes marital rape has rejected the international outcry as foreign meddling.

饱受批评的一项法律的拥护者说合法化的婚内暴力不会受国际舆论的干涉。

Years ago, a ancient Egyptian fleet went to the Land of punt for seeking a kind of flavor named "myrrh", and aromatic plants which has dense exotic style for the queen Hatshepsut.

3500年前的一个古埃及的舰队到&彭特之地&寻找一种叫没药的香料。