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The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system, such as neurodegenerative diseases, The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

本发明的化合物还可用于预防和治疗TRX-介导的疾病，例如自身免疫性、变应性和炎性疾病，并且用于预防和/或治疗中枢神经系统疾病，例如神经变性性疾病。本发明还提供了包含所述异羟肟酸衍生物的药物组合物以及这些药物组合物的易于依从并且在体内产生治疗有效量的所述异羟肟酸衍生物的安全剂量方案。

The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

此外，本发明提供了药物组合物，其包含所述的异羟肟酸异羟肟酸衍生物，本发明还提供了这些药物组合物的安全的剂量给药方案，其可以容易地遵照，并且其在体内产生该异羟肟酸衍生物的治疗有效量。

The drug release experiments in vitro indicated that with the increase of PLA molecular weight, the drug release rates decreased. 4ac releasing from 4ac-PLA-NP could be characterized by Weibull's equation. The interaction between 4ac and others compositions was not detected by DSC. The peak position of 4ac in DSC did not changed comparing 4ac with 4ac-PLA-NP lyophilize injection. Thc X-ray result showed that the peak of 4ac-PLA-NP was piled up between 4ac and other compositions.

差示扫描量热分析结果表明药物与各组分之间无明显的相互作用，制成4ac-PLA-NP冻干针剂后，其放热峰主要表现为聚乳酸的放热峰：X-射线衍射结果表明药物与载体间无相互作用，4ac-PLA-NP主要表现为4ac与载体之间的叠加峰；TLC、FT-IR也同样表明药物与载体无相互作用，它们之间是一种物理结合，并未有新物质生成。

Objective: To develop a GC-MS method for the determination of pseudo-ephedrine in human plasma and study the mutative rules of the pharmacokinetic parameters of the pseudo-ephedrine in different compositions. Method: Orthogonal design was used to determine 8 compositions from Mahuang decoction.

中文摘要：目的：以君药效应成分伪麻黄碱(pseudo-ephedrine，PE)为指标，用GC-MS法考察不同配伍对PE药代学参数的影响规律，探索麻黄汤方中臣佐使药对君药人体内过程的影响。

The characteristic compositions of the stable isotopic and the fluid inclusions in Maoping mineral district show that the main sources of Pb origin the Upper Earths Crust, partly froin orogenetic belt and/or Emeishan basalt; the S isotopic composition hints sulfur sources from the seawater; The D and O isotopic compositions show that they emerge from the compound results of the magma water, metamorphic water, hosted water and rain water; the origination of the C isotopic shows that C resource strata.

脉石矿物D、O同位素组成代表了岩浆水、变质水、建造水及大气降水混合作用的结果；C同位素组成则反映来自受热液改造的含有机质的地层，说明地层受成矿流体溶解、淋滤、萃取而提供了部分成矿物质和储矿空间。

The second group are the mixtures of Jurassic coal-formed oils and Cretaceous-derived oils. The carbon isotope, n-alkanes and isoprenoids compositions of these oils are similar to core extracts from Jurassic coal measures. However, sterane and terpane compositions of these oils show affinity to Cretaceous source rocks. It is deduced that coal-formed oils dissolved the biomarker-rich Cretaceous bitumen of relatively low thermal maturity, and overprinting occurs during oil migration.

第二类原油具有侏罗系煤系烃源岩与白垩系湖相泥质烃源岩混源的特点，这类原油的碳同位素组成、正构烷烃分布特征和姥植比等均表现出煤成油的特征，但甾、萜烷烃类化合物组成与白垩系烃源岩接近，推测是由于侏罗系煤成油在向上运移成藏过程中，受到成熟度相对较低、生物标志物相对丰富的白垩系烃源岩的浸析作用所致。

In general, the distribution of stable carbon and nitrogen isotopes revealed the mixing inputs of terrigenous and marine organic matter controlled the stable carbon and nitrogen isotope compositions in sedimentary organic matter. However, a series of physical, chemical and biogeochemical processes occurring in the local environments had also the significant influence on the stable carbon and nitrogen isotope compositions in organic matter.

研究区域内，稳定碳、氮同位素的地区分布和季节变化特征揭示，有机质中稳定碳、氮同位素组成不仅受陆源和海源有机质输入量之间消长变化的影响，同时一系列的生物地球化学过程、人为有机质的输入和沉积物粒度与叶绿素含量对碳、氮同位素组成均存在一定的改造作用。

Results The compositions of 28 Chinese herbs can inhibit the growth of 5 bacteria in different levels, but the effects on other 3 bacteria are not obvious. Quercetin and usnic acid have better effects on 5 bacteria than other 26 herbs compositions, with MIC 0.03125～0.125mg/ml and 0.0156～0.0625mg/ml.

结果 28种中药有效成分对3种牙周细菌抑制作用不明显，对另5种口腔常见细菌有一定的抑制作用，其中松萝酸和槲皮素有较强的抑菌作用，MIC值分别在0.0156～0.0625mg/ml和0.3125～0.125mg/ml之间。

The article initiates from Lobos living background and music innovation career, tries to reveal unique Brazilian characteristic implicated in his piano compositions, furthermore, to affirm his outstanding contribution to Brazilian nationali music compositions.

文章从分析他的生活背景以及音乐创作生涯着手，力求展现他在钢琴作品领域中所展现的独特的巴西风情，从而深入肯定他在致力于巴西民族音乐创作上的突出贡献。

A systematic study on S and/or Pb isotopic compositions of the copper-bearing porphyries, ore minerals and andesite of the deposit shows that S isotopic compositions of ore minerals are similar to those of porphyries.

矿石矿物（208Pb/204Pb=37.917~38.230，平均值38.075；207Pb/204Pb=15.528~15.614，平均值15.571；206Pb/204Pb=17.929~18.082，平均值17.981）与矿化斑岩(208Pb/204Pb=37.832、37.883，207Pb/204Pb=15.529、15.538，206Pb/204Pb=17.906、17.910)以及安山岩(208Pb/204Pb=37.816~37.884，207Pb/204Pb=15.549~15.562，206Pb/204Pb=17.845~17.919)的初始铅组成基本一致，变化范围较小，表明三者具有相同的来源；在铅构造模式图上，所有样品铅同位素均位于造山带演化线上或附近，在铅同位素源区判别图中，均落入造山带和下地壳区域，这表明Pb主要来源于壳幔混合。

I'm strongly against the death penalty — it's an eye for an eye.

我不赞成死刑——这是以牙还牙的报复行为。

And to get you the support you need, we're enlisting all elements of our national power: our diplomacy and development, our economic might and our moral suasion, so that you and the rest of our military do not bear the burden of our security alone.

并给你们所须的支援，我们正徵召国家所有各种的力量：我们的外交及发展，我们的经济力量与道德劝说，所以你们与其他军人不须要孤独地负起国家安全的责任。