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The present invention is directed to substituted propylamine derivatives of formula I or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

本发明涉及式I的取代丙胺衍生物或其医药学上可接受的盐、含有这些衍生物的组合物、和其用于预防和治疗通过单胺再摄取改善的病状的使用方法，所述病状尤其包括血管舒缩症状、性功能障碍、胃肠道和泌尿生殖道病症、慢性疲劳综合症、纤维肌痛综合症、神经系统病症和其组合，特别是那些选自由严重抑郁症、血管舒缩症状、压力性和急迫性尿失禁、纤维肌痛、疼痛、糖尿病性神经病变和其组合组成的群组的病状。

The somatic hybrids usually showed specific bands and combined all the bands of both parents. In combinations, some new bands were detected, and occasionally specific bands of parents were lost, which indicated that chromosome recombination and exchange happened after fusion. Additionally, in some combinations, specific bands from leaf parent were detected, which revealed the plants were of putative hybrid origin, because leaf protoplast cannot redifferentiate by both single culture and co-culture.

体细胞杂种一般表现为具有双亲的特征带，且综合双亲的所有带，但在部分杂种中检测到了双亲都没有的新带，也发现有丢失亲本的特征带或共有带的现象，说明融合后染色体发生了重组和交换；有的引物只检测到叶肉亲本的特征带，根据柑橘叶肉细胞无论单独培养还是共培养均不能再生的事实，可推测其为体细胞杂种或二倍体叶肉亲本型胞质杂种。

The paper has calculated the critical volume combinations of some left turn rates and drawn the critical volume combinations curves, which can be used to justify a left-turn-lane at unsignalized T-intersection.

利用此曲线可判定无信号T型交叉口是否需要设置左转车道，对无信号交叉口的规划、设计、建设和管理等工程实践具有重要的指导意义。

The GCA and SCA between various parents and cross combinations were significantly different. The GCA effect value of 582 was the highest in these three traits. The sum of breeding value and SCA of cross combination 582×Kangda was significantly superior to other combinations in amount of cocoon crop and cocooning rate to newly hatched larvae. The best cross combination of breeding value and SCA was 582×9906 in thousand-cocoon weight.

供试亲本间及各组合间的GCA和SCA差异较大，其中亲本材料582的产茧量、千粒茧质量及收蚁结茧率3个性状均表现出最高的GCA效应值；杂交组合582×抗大的产茧量和收蚁结茧率的育种值与SCA之和明显地优于其他组合，千粒茧质量的育种值与SCA之和最优的组合为582×9906。

In recent years, fixed dosed combinations are all named and single pure combinations are widely used in western countries and recommended by guidelines.

近几年，固定剂量复合剂都被命名了，单一纯粹的复合剂在西方国家广泛使用，并被指南所推荐。

The players in different positions have different action combinations in the match. The action combination group is made of different action combination. The players, body action in the match is mostly reflected by action combinations.3. The setter has the most average HR among the match in our excellent men volleyball players. The HR is 143 times every minutes; the assistant spikier,s HR is 136.5 times every minutes; the spikier,s HR is 127 times every minutes; the assistant setters HR is 121.5 times every minutes; and the libero,s HR is 136.5 times every minutes.4. There are some questions in the exercise on specialized physical constitution of our men and women volleyball players. The questions are: the principle about the wholly exercise is not clearly bodied; the exercises are not perfectly coincided the position distinguishing; the exercises of specialized physical constitution are not prominent; the content about the exercises of specialized physical constitution is not like the match.5. The excellent volleyball players in different positions have the different demands on the specialized physical constitution.

不同位置运动员在比赛中表现出的动作组合形式不同，不同的动作组合之间相结合又形成了不同的动作组合集，运动员在比赛中的身体活动主要是以动作组合集的形式表现出来的。3我国优秀男子排球运动员，在一场比赛中，二传的平均心率最高，为143次/分；副攻平均心率为136.5次/分；主攻的平均心率为127次/分；接应二传的平均心率为121.5次/分；自由人的平均心率为109.5次/分。4目前我国国家男排和女排运动员专项身体素质训练还存在一些问题，主要体现在四个方面：1、专项身体素质训练整体性原则体现不足2、没有很好地结合排球运动员专项身体素质的位置特征3、专项身体素质训练重点不突出4、专项身体素质训练内容不贴近比赛实际。5不同位置优秀排球运动员对专项身体素质的发展要求不同，或者说排球运动员专项身体素质具有位置特征。

Genetic diversity of 105 Chinese key cottons with Fusarium and Verticillium wilts resistance was studied based on AFLP markers. Twenty primer combinations were selected to perform the AFLP fingerprinting from 100 primer combinations.

利用AFLP分子标记技术，对我国20世纪50年代开展抗枯、黄萎病育种以来培育的105份骨干品种的遗传多样性进行了研究。

And with six stripe options in the new wider configuration, five different interior color combinations, four different wheel choices and three available interior bezels; the 2010 Viper SRT10 will be available in more than 7,600 combinations-the most for any one model year-significantly adding to the exclusivity of each car like never before.

并有6个新的更广泛的配置条纹选项，五个不同的内饰颜色组合，四个不同的三个车轮的选择和使用内部盖的，2010年蝰蛇SRT10将超过7600组合，是任何一个车型年最显着增加可用到每个喜欢汽车独家前所未有的。

The fusion DNA fragments of ag85b-mpb64 and ag85b-mpb64-esat-6 were obtained by PCR andSOE technique. Various DNA vaccines were constructed with the pcDNA3.1: fusion of two genes, and of three genes, bivalent combinations and trivalent combinations(pCA+pCM+pCE6). BALB/c mice were vaccinated with this DNA vaccines.The mice injected withBCG were positive control and the mice injected with pCDNA3.1 and PBS were negative control.The mice were immunized 3 times with 2-wk intervals. The animals in group BCG were only inoculatedsubcutaneously with 1×10~6 CFU BCG at initial vaccination. The serum IgG titers and IgG isotype weredetermined using iELISA coated with M. bovis PPD and rMAE protein expressed and depurated inprokaryotic expression system every week.

同样，利用PCR和SOE技术，获得牛分枝杆菌mpb64-ag85b和mpb64-ag85b-esat-6融合基因，以pCDNA3.1为载体构建了牛分枝杆菌多价组合和多基因融合DNA疫苗：二基因融合(pCDNA3.1-MPB64-Ag85B，简称pCMA)和三基因融合(pCDNA3.1-MPB64-Ag85B-ESAT-6，简称pCMAE)DNA疫苗；二价组合和三价组合(pCA+pCM+pCE6)DNA疫苗，免疫BALB／c小鼠，以牛分枝杆菌BCG免疫组为阳性对照，以pCDNA3.1及PBS免疫组为阴性对照，共免疫3次，每次间隔2周，BCG组仅初免时皮下免疫1次。1免后每周，以原核表达纯化的重组MPB64-Ag85B-ESAT-6蛋白和牛分枝杆菌PPD为包被抗原，以间接ELISA方法检测血清IgG水平及lgG亚类。

In addition to the headwords of main entries, it contains 157,000 combinations and derivatives in bold type, and 169,000 phrases and combinations in bold italic type, making a total of 616,500 word-forms.

除了主条目的慈母，本词典还包含15万7千词组和粗体的衍生词，以及粗体和斜体的16万9千条短语和词组，总共61万6千5百种单词形式。

Objective To investigate the effects of interleukin-1 β converting enzyme gene on the biologic characteristics of ovarian cancer cells.

目的 探讨白细胞介素-1 β转换酶的表达，对卵巢癌细胞生物学特性的影响。

Campylobacter: This illness is the most commonly identified cause of diarrheal illness in the world.

弯曲：这种病是最常见的原因查明腹泻病，在世界上。