查询词典 candidas

Increasing of the proliferation and differentiation of lymphocytes in LP were found. Conclusions Lymphocyts in LP play an important role on the mucosal immunity of SPF mice when they are first inoculated with Candidas. The reducing amount of Candidas in intestine is related to increasing of the specific IgA antibodies in the intestinal mucus.

带菌动物首次白念菌肠内给入后以固有层中淋巴细胞反应为主，增殖及分化均增加；白念菌总量和粘附数量减少与局部粘膜免疫反应及特异IgA抗体含量上升的关系十分密切。

Results From the third day to the fourteenth day after Candidas inoculation, the amount of Candidas colonization in lumen and that attached to mucosal membrane reduced sharply. Candida translocation into MLN happened in the early time after inoculation and were not found in the later time. At meanwhile same time the content of specific IgA increased obviously.

结果 肠内白念菌总量及粘膜表面粘附数量随给菌后时间延长而明显下降；移位主要发生于给菌后早期；给菌后固有层淋巴细胞增殖活跃，分泌IgA浆细胞数量明显增加；粘液层中特异抗白念菌IgA含量在给菌后上升明显。

objective to establish immunological methods specific for detecting antigens in different groups of monoclonal antibodies.methods indirect immnofluorescence assay was applied to identify specificity of the two groups of monoclonal antibodies prepared with crude antigen and recombinant antigen of aspergillus fumigatus,respectively.two different double monoclonal antibody sandwich elisa assays established with the two groups of antibodies were performed to detect antigents in the cell culture supermatants of 19 common species of aspergillus,penicillium marneffei,and 5 species of candidas.results the results of indirect immnofluorescence assay indicated that the monoclonal antibodies prepared with crude antigen of aspergillus fumigatus were specific for antigens in both clinical isolates and environmental isolates of aspergillus, whereas the other group of monoclonal antibodies was proved to be specific for aspergillus fumigatus of both clinical and environmental isolates.the elisa assay established with the crude antigen-specfic monoclonal antibodies could detect both of the clinical and environmental isolates of aspergllius, while the other assay could only detect aspergillus fumigatus of both clinical and environmental isolates.and no cross reaction with the cell culture of penialllium marneffei and candidas was observed with the two methods.conclusion the elisa assays can detect both of the clinical and environmental isolates of aspergillus,and differentiate aspergillus fumigatus from other species of aspergillus.

目的 用2组曲霉单克隆抗体建立特异性识别不同种类曲霉抗原的检测方法。方法采用天然烟曲霉抗原免疫，获得广谱针对曲霉抗原的单克隆抗体；采用重组烟曲霉抗原获得特异性针对烟曲霉抗原的单克隆抗体，用间接免疫荧光鉴定，并分别建立2种双抗体夹心elisa法，对19种常见的环境和临床分离曲霉株、马尔尼菲氏青霉菌及念珠菌培养液进行检测。结果间接免疫荧光显示，用天然烟曲霉抗原免疫获得的单克隆抗体(mabs-1)可广谱识别多种曲霉分离株，而重组烟曲霉抗原获得的单克降抗体(mabs-2)仅能特异性结合临床和环境分离的烟曲霉抗原。用mabs-1建立的双抗体夹心elisa法可检测19种常见曲霉株培养液；用特异性针对烟曲霉抗原单克降抗体(mabs-2)建立的双抗体夹心elisa法可特异性检测临床和环境分离株烟曲霉培养液；与其他曲霉株无交叉反应；2种双抗体夹心elisa法与马尔尼菲氏青霉菌及念珠菌培养液均无交叉反应。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Mygoal for the website, as it is in the Annual Letter, is to be as candidas I can about the issues I care about.

与年度信如出一辙，我开设网站的初衷也是想诚恳地探讨那些我所关心的事件。

The candida albicans and candidas tropicalis was more common in clinical samples, and the positive rate of drug resistant strain against fungus increased gradually. So it is important to culture, isolate and identify the fungus from clinical samples, and do the antifungal sensitivity at the same time.

临床上酵母样真菌感染以白色念珠菌和热带念珠菌较常见；真菌耐药菌株的检出率呈上升趋势，临床上必须重视真菌的检出和药敏试验。

At PCD3 and PCD7,the number of candidas was higher,but it decreased at PCD14.At PCD14,IL-4 expression in PP was the highest, while at PCD7 IL-6 expression in LP was the top one.

结果 白色念珠菌总数以定植3 d，7 d较高，14 d则明显下降；PP中IL-4表达以定植14 d最高；LP中IL-6阳性细胞数增加以定植7 d最高。

Based on the backgrounds above-mentioned, our research intends to understand the incidence and the distribution of Candidas in the fungal infection cases and among healthy volunteers, mensurate the MIC of several antifungal agents against Candida ioslates in oral cavity, and to understand the difference of sensitivity in order to helpclinicians select proper antigungal agents, and discuss the relationship between antifungal susceptibility and clinical effect.

基于上述研究背景，本试验的研究目的是了解当前口腔念珠菌感染患者和健康人口内菌株的检出及分布情况；测定几种常用抗真菌药物对念珠菌口内分离株的最低抑菌浓度，了解其药敏感性有无差别，为临床用药提供参考；初步探讨MIC值与临床疗效的关系。

Results In this 323 strains of fungus, candida albicans was the main species, according for 63.8％, candidas tropicalis for 22.3％, and candidasglabrata for 7.4％.The resistance rate to 5 antifungals was ordinalhere:5FC 1.9％, AP 2.2％, KE 5.6％, IT 10.2％, FL 12.1％.

结果：323株真菌中，白色念珠菌、热带念珠菌、光滑念珠菌等分别占63.8%、22.3%和7.4%；对5种常用抗真菌药的耐药率排序依次为：5氟胞嘧啶1.9%、****霉素B2.2%、酮康唑5.6%、依曲康唑10.2%、氟康唑12.1%。

Methods Indirect immnofluorescence assay was applied to identify specificity of the two groups of monoclonal antibodies prepared with crude antigen and recombinant antigen of Aspergillus fumigatus,respectively.Two different double monoclonal antibody sandwich ELISA assays established with the two groups of antibodies were performed to detect antigents in the cell culture supermatants of 19 common species of Aspergillus,Penicillium marneffei,and 5 species of Candidas.

采用天然烟曲霉抗原免疫，获得广谱针对曲霉抗原的单克隆抗体；采用重组烟曲霉抗原获得特异性针对烟曲霉抗原的单克隆抗体，用间接免疫荧光鉴定，并分别建立2种双抗体夹心ELISA法，对19种常见的环境和临床分离曲霉株、马尔尼菲氏青霉菌及念珠菌培养液进行检测。

Cable dampener cannot be rolled up but must be hung over the cable.

缆帆不能被卷起，必须保证处于展开状态

"This skylark is a present from my master," he says.

"这只云雀是我主人献上的礼物。"他说。