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However, chronic repetitive administration of beta-adrenoceptor agonists may increase AHR, airway inflammation, and risk of death.

然而长期反复使用β受体激动剂也可能增加气道高反应性、气道炎症和死亡的风险。

However,chronic repetitive administration of beta-adrenoceptor agonists may increase AHR, airway inflammation, and risk of death.

但持续使用β-肾上腺素受体激动剂可能会增强AHR，扩大炎症反应，增加死亡率。

Addition of anticholinergic solution prolongs bronchodilator effect of beta 2 agonists in patients with chronic obstructive pulmonary disease.

吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗慢性阻塞性肺疾病的疗效与安全性比较。

In vitro DA and its agonists apomorphine could only inhibit GTH release induced by GnRH and could not inhibit basal GTH release, the results were agreement with that in vivo.

DA不能抑制长臀鮠脑垂体碎片基础GTH的分泌，而只能抑制GnRH诱导的GTH的分泌，与在体注射的结果一致，APO的效果和DA相类似。

METHODS: The skinned first class arborization of superior mesenteric artery from HS rats were adopted to observe the influence of inhibitor of ZIPK on the effects of PKCα and PKCε agonists on calcium sensitivity after shock via measuring the contraction initiated by Ca2+ with isolated organ perfusion system, hypoxic vascualr smooth muscle cells were adopted to measure the protein expression and activity of ZIPK after applying PKCα and PKCε agonists following hypoxia via Western blotting.

采用离体微血管环张力测定技术，观察褪膜后抑制ZIPK对PKCα、PKCε激动剂增高失血性休克肠系膜上动脉一级分支微血管钙敏感性作用的影响；同时观察缺氧血管平滑肌细胞在PKCα、PKCε激动剂作用下ZIPK蛋白表达、活性的变化。

Our result showed the expressed HμOR desensitization could be induced by acute stimulation of μ-selective agonists DAGO and Ohm in a dose-dependent manner in G protein level.

在昆虫细胞表达的HμOR，用μ选择性激动剂DAGO和Ohm急性预处理，也同样导致HμOR的脱敏，并且随着预处理激动剂浓度增加，脱敏现象愈明显。

The up-regulation of 〓 receptor may be an important factor in AIM seen in long-term treatment of parkinsons disease with 〓-dopa; and the deterioration of response to DA-agonists may be associated with the down-regulation of 〓 receptor.

长期应用1—dopa等药物治疗帕金森病过程中伴发的AIM，〓受体的上调可能是一个重要因素，药效衰减与〓受体下调密切相关。

However,highly selectiveκagonists produced transient sedation and emesis,although tolerance developed to these effects during chronic treatment.

许多证据表明传统高选择性κ-受体激动剂不仅具有较高的镇痛作用，而且还克服了与μ受体相关的副作用，尤其是能够抑制阿片类物质成瘾。

Stimulation of the cells with specific agonists significantly induced DOR phosphorylation, whereas phosphorylation of KOR was not detected under the same conditions.

表达的DOR和KOR主要定位于细胞膜表面，与相应受体亚型特异性激动剂结合后能激活膜上的G蛋白。2，在NG108-15细胞中，DOR和KOR均主要以非磷酸化形式存在。

In this study, We typed the the gene of β〓-AR from genomic DNA of asthmatic patients and made the further analysis: The distributing condition of genetic polymorphisms at positions 16 and 27 in β〓 AR coding region and at position 19 in 5'Leader Cistron (5'LC) among southwest Chinese asthmatic population; The relationship between the each polymorphisms at the above three positions and the asthmatic phenotypes (FEV〓 or nocturnal asthma); The effect of each polymorphisms at the above three positions on bronchodilator responsiveness induced by β〓- agonists(initial bronchodilator response, pharmaco-dynamic); The relationship between the haplotypes of polymorphisms in the 5'LC or in positions 16, 27 of β〓AR coding block and asthmatic phenotypes or bronchodilator responsiveness induced by β〓-agonists.

实验通过对哮喘人群的β〓-AR基因进行分型，探讨：β〓-AR编码区16、27位点及5'前导肽(5'LeaderCistron，5'LC)19位点遗传多态性在中国西南地区哮喘人群中的分布情况；三个位点多态性与哮喘临床表现型的关系；三个位点多态性对β〓受体激动剂反应性(支气管舒张反应，舒张反应动力学)的影响；16、27位点及5'前导肽19位点遗传多态性单倍型与哮喘临床表现型及β〓受体激动剂反应性的关系。

On closer examination, though, this is not a vote for multilateralism but just the opposite.

仔细审视后我们发现，这并非是对多边主义投出的赞成票，而是恰好相反。

Uncovering their weak spots, so I can defeat them.

揭露出他们的弱点，这样我就可以打败他们了。