查询词典 activation

This model was finely fitted by theexperimental results and was used to calculate the activation area,which was 0.127 〓/mol with little dependence of subphasetemperature. The positive activation area indicate that there is anincrease in area when the activated complex is formed, increasingthe surface pressure should decrease the rate constant and that theactivated complex is unimolecular in nature.

在一系列实验曲线的基础上，我们提出测量的面积变化应该由聚合中分子结构变化引起的急剧的瞬时面积变化与随后的与此面积变化相反的弛豫过程两部分组成，并据此提出一种反应动力学模型，此模型与实验结果相当吻合，此模型用于处理聚合速率的紫外光强依赖性，得到聚合速率常数近似与光强成二次幂指数关系；此模型也被用于计算活化面积，发现活化面积为〓，几乎与温度无关。

Our results indicate that 1 NSC606985, at nanomolar level, can effectively induce apoptosis in AML cells NB4 and U937 and significantly inhibit the proliferation without cell death in breakpoint cluster region–Abelson murine leukemia kinase-carrying leukemic K562 cells; 2 At such low concentrations, this agent also significantly inhibits the clonogenic activity of hematopoietic progenitors from patients with AML; 3 For apoptosis induction, NSC606985 rapidly induces the proteolytic activation of protein kinase Cδ with loss of mitochondrial transmembrane potential and caspase-3 activation; 4 Co-treatment with rottlerin, a PKCδ-specific inhibitor, completely blocks NSC606985-induced mitochondrial m loss and caspase-3 activation, while the

结果显示：(1)纳摩尔浓度的NSC606985即可有效诱导AML细胞系NB4和U937细胞凋亡并显著抑制含有bcr-abl融合蛋白激酶的K562细胞的增殖；(2)低浓度的NSC606985也显著抑制来自AML病人骨髓的新鲜白血病细胞的克隆形成能力；(3)除了迅速诱导线粒体跨膜电位的崩塌及Caspase-3的活化外，NSC60698也导致蛋白激酶Cδ的水解激活；(4)PKCδ特异的抑制剂rottlerin能够完全抑制NSC606985诱导的线粒体跨膜电位的崩塌和Caspase-3的活化，而Caspase-3特异的抑制剂z-DEVD-fmk仅能部分削弱PKCδ的活化及细胞的凋亡；(5)以移植PML-RARα转基因小鼠产生的白血病细胞建立的模型研究了该化合物对白血病可能的治疗作用。

Taken together, our data showed that both the CSF-box and the octamer are important for the LPS-induced G-CSF promoter activity, moreover, the activation of MEK/ERK signaling pathway is indispensible for LPS-induced G-CSF expression in RAW264.7 macrophage.. It seems that LPS-induced activation of MEK/ERK pathway does not directly regulates NF-κB transactivity, but is essential for LPS-induced Oct-2 binding to the octmaer within G-CSF promoter and transcription activation of the G-CSF expression.

透过这些结果，我们认为MEK/ERK pathway的确参与LPS活化G-CSF表现的过程，虽然MEK/ERK pathway都影响了CSF-box以及octamer对G-CSF启动子所贡献的活性，但似乎MEK/ERK pathway的下游并非直接影响NF-κB调控基因转录的活性，而主要是影响了Oct-2对G-CSF启动子的调控。

Among the three kinds of activation methods, electrical activation was the best with (67.75±1.03)% oocytes cleavage rate and (13.52±2.05)% morulae rate. The best parameters for electrical activation was 130 V/mm and 80 μs.

电激活比乙醇激活、A23187激活有更高的卵裂率(67.75±1.03)%和桑椹胚率(13.52±2.05)%，且差异显著(P.05)，最佳激活参数为130V/mm、80μs、一次脉冲激活。

Artificially induced a single 〓elevation could effectively drive the activation, in recently ovulated oocytes (12—13 h after hCG) however, a single Ca〓 increase was futile in initiation of activation and only repetitive 〓 rises were avalable, suggesting that the activation of recently ovulated oocytes requires oscillatory Ca〓 signals as occuring at fertilization.

只有诱导卵内Ca〓多次升高才能使之激活。提示：刚排出不久的卵激活象受精一样需要胞质Ca〓波动信号。

The research show that from anthracite, lean coal to bituminous, reaction rate become more and more large and ignition activation energy become more and more small; ignition activation energy falls and reaction rate increases as the volatile content increases;With the carbon content of dry ash-free basis increasing, ignition activation energy increases and reaction rate falls.

结果表明：从无烟煤，贫煤到烟煤，其反应速率越来越大，频率因子越来越小，着火活化能越来越低；挥发分增加，活化能减小，反应速率变大；干燥无灰基固定碳含量增加，着火活化能增加，反应速率减小。

Results The activation of NF-κB, proliferation response, and expression of IL-4 and I L-5 mRNA and protein in T lymphocytes stimulated by PMA were significantly hig her than those of their blank control (P.01), while those indexes of T l ymphocytes stimulated by PMA and PDTC simultaneously were significantly lower th an those stimulated by PMA alone (P.01). The apoptotic index of T lympho cytes stimulated with PMA were significantly lower than that of their blank cont rol (P.01), and the apoptotic index of asthmatic guinea pig T lymphocytes stimulated with PMA and PDTC simultaneously were significantly higher than that stimulated by PMA alone (P.01). The significant positive correlations w ere found between the activation of NF-κB and the proliferation (r=0.64, P.001), and the expression of IL-4 and IL-5 mRNA and protein of T lymph ocytes, respectively (r=0.55-0.68, P.001). There was also signific ant negative correlation between the activation of NF-κB and apoptosis of T l ymphocytes (r=0.62, P.001). Conclusions NF-κB may participate in the signal conduction of PKC regulated proliferation, apoptosis and expression of IL-4 and IL-5 of T lymphocytes in asthma.

结果加入PMA培养的哮喘组T淋巴细胞NF-κB的活化、细胞增殖反应、IL-4和IL-5的mRNA和蛋白质的表达均显著高于其空白对照(P.01)，而同时加入PMA和PDTC培养的哮喘组T 淋巴细胞以上指标均显著低于只加入PMA培养的哮喘组T淋巴细胞(P.01)；加入PMA 培养的哮喘组T淋巴细胞的凋亡指数显著低于其空白对照(P.01)，而同时加入PMA 和PDTC培养的哮喘组T淋巴细胞凋亡指数显著高于只加入PMA培养的哮喘组T淋巴细胞(P 。01)。T淋巴细胞NF-κB的活化与增殖反应呈显著正相关(r=0.64，P.00 1)，与IL-4和IL-5的mRNA和蛋白质的表达也均呈显著正相关(r=0.55-0.68，P 。001)，而与凋亡指数呈显著负相关(r=-0.62，P.001)。

PCF significantly abolished activation of JNKs and p38 kinase activation while enhanced ERKs activation.

PCF还能提高磷酸化ERK的活性但降低磷酸化JNK及磷酸化P38的活性。

RESULTS: Analysis of T cell activation in vitro revealed that preincubation of PBMC with 100 μmol/L gossypol could completely inhibit the expression of early activation marker CD69 on CD3+ T cells in response to 10 mg/L PHA, and block T cell activation by 10-7 mol/L PDB as well.

结果： 100 μmol/L的棉酚预先与T细胞温育，能完全抑制10 mg/L植物血凝素刺激的CD3＋T细胞活化抗原CD69的表达，又可阻断10－7 mol/L佛波醇酯对T细胞的活化作用。

Characters of various brain areas: In ADHD without Ritalin, the prefrontal lobe , basal ganglia , cerebellum, anterior cingulate gyrus , cerebellum and right inferior parietal lobulus showed lower activation than that of controls on IC. On IC in ADHD without Ritalin, activation of PFL remained lower than that in controls, GaC was similarly activated to that in controls. But on IC in ADHD without Ritalin, the activation of BG, cerebellum and right LPI was higher than that in controls.

不同脑区激活特点：ADHD患儿完成冲突任务时前额叶、基底节、小脑以及右侧顶下小叶激活程度低于对照组；完成中性任务时，前额叶激活程度较对照组弱，扣带回前部激活程度与对照组相似，而基底节、小脑、右侧顶下小叶激活程度较对照组强。

It is also known as one of the most poisonous naturally occurring substances.

它也被称为一个最自然发生的有毒物质。

The greatest stress is found at the location on the cross section where V is the largest.

最大应力出现在横截面上V为最大的地方。