查询词典 Ala

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用，保护作用的机制是多方面的，除了改善糖脂代谢，降低血压外，还具有保护小血管内皮，改善凝血和纤溶系统活性，抗炎症等多方面的作用，且作用随着用药时间的延长而日趋明显，在疾病的早期应用效果更佳，故提倡早期用药；对伴有慢性肾功不全的患者，罗格列酮对肾脏靶器官的保护作用显现的并不明显，但副作用与对照组无明显差异，不用根据肾功情况调整用药，但由于样本量较小，上述结论尚需大样本进行进一步证实；本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异，糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性，Prol2Ala与糖尿病及糖尿病肾病不相关。

The bioinformatics analysis of the deduced amino acid sequences of four genes indicated they are classical AGPs. They contain an N-terminal signal sequence, a central domain rich in Ala, Ser, Thr, Pro/Hyp, and C-terminal hydrophobic transmembrane domain. All of them include two AGP-like domains(rich in noncontinuous Pro residues) and a putative C-terminal GPI anchor signal sequence.

对四个基因编码的蛋白序列进行生物信息学分析，发现它们都包含N端信号肽序列，具有富含Ala、Ser、Thr、Pro／Hyp的长度可变区以及C端疏水跨膜区，还具有两个富含非连续Pro的AGP-like domain，C端存在可能的GPI锚定区。

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物，我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板，设计了一系列能抑制furin和kexin活性的突变体，采用如下三种方法逐步优化：一、去除Lys片段长链三对二硫键中的一对，用Ser替换Cys，减少可能存在的二硫键错误配对；二、抑制剂的活性中心根据furin底物的专一性逐步改变，即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg，同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用，将P7位Asp替换为Ala；三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

ALA is sulfury.

ALA 含硫磺的。

The biological activity of two immunologically similar recombinant grass carp growth hormone were compared with recombinant tuna Thunnus thynnus growth hormone, as well as an analog of LHRH(D—Ala~6, Pro~9—N—Etylamide—LHRH, LHRH—A).

本文对两种具有相似免疫活性的草鱼基因重组生长激素(r—gGH—Ⅰ、r—gGH—Ⅱ)的生物活性进行了初步研究，并把它们对草鱼鱼种生长的促进能力与金枪鱼基因重组生长激素的一种高效类似物LHRH—A(D—Ala~6，Pro~9—N—Etylamide—LHRH)进行了比较。

All patients underwent anterior vertebrectomy and decompression; anterior fusion was carried out with costal or iliac ala grafts.

所有患者均进行了前路椎体切除减压，并用肋骨或髂骨进行了前路植骨融合。

Rub nose method is: The side outside using two tactics big toe chafes each other, when feeling having heat, two side massage bridge of the nose of edge of the side outside the big toe that use a hand, nose ala 30 times or so up and down.

摩鼻的方法是：用两手拇指外侧相互摩擦，在有热感时，用手拇指外侧沿鼻梁、鼻翼两侧上下按摩30次左右。

Therefore, to deal with this problem effectively, we need not only to concretized, and restrict the "intolerable" standard, but ala must be take full advantages of the judge, the scholar and even the individual citizens who may play an active role in solving this problem.

因此，为了有效处理这一问题，我们不仅需要对&无法忍受&标准适作进一步的具体化与相应地限缩，同时也必须充分发挥司法者、学者乃至公民个人在应对此一问题上的积极作用。

At the time of King's visit the Supreme Court had ruled that the desegregated bus system in Montgomery, Ala., he opposed was unconstitutional.

在马丁路德金访问的时候，最高法院就已经裁定了阿拉巴马州蒙哥马利市有种族隔离的公交系统，他的反对是违宪的。

At the time of Kings visit the Supreme Court hadruled that the desegregated bus system in Montgomery, Ala., heopposed was unconstitutional.

在马丁路德金访问的时候，最高法院就已经裁定了阿拉巴马州蒙哥马利市有种族隔离的公交系统，他的反对是违宪的。

World War II: Battle of Saipan - Americans take Saipan.

1944年的今天，美国在塞班战役中拿下塞班岛。

When the scorner, the rejecter of truth, has become presumptuous; when the routine of work in the various money-making lines is carried on without regard to principle; when the student is eagerly seeking knowledge of everything but his Bible, Christ comes as a thief.{DA 635.3

当讥诮和拒绝真理的人，到了任意妄为时，当追求财利者罔顾按道义经营谋利时，当学人正在兢兢业业地研究各种知识，而单把圣经丢在一边时，基督要像贼一样来临。