bone up

Osteoporosis is a disease characterized by low bone mass and deterioration of microarchitectural bone tissue. The changes of bone tissue cause systemic bone pain, lumbago, arthrodynia, a increase in bone fragility and susceptibility to fractures, especially the danger of traumetic and spontaneons fracture. It severely demages the health and living quality of the aged.

骨质疏松症是一种以低骨量和骨组织显微结构退化为特征的疾病，骨组织的变化引起全身骨痛、腰背痛、关节痛等，并导致骨脆性增加，从而增加骨折危险性，易发生外伤性和自发性骨折，其严重危害老年人的身体健康和生活质量。

Clinical study indicated: the flavone of rhizome drynaria can promote collagen synthesis, improve bone transition, increase bone formation, delay bone resorption, furthermore, improve SOP patients' integer bone mass and proximate of femur bone strength, and prevent fracture of hip.Eventually, the level of living independence amended and the quality of life improved overall.

临床研究表明：骨碎补总黄酮具有促进老年性骨质疏松症骨胶原的合成，提高骨转换，增加骨形成，减缓骨吸收状况等作用，进而提高老年性骨质疏松的整体骨量，缓解腰背痛，提高股骨近端骨强度，预防髋部骨折，提升独立性生活水准，全面提高老年性骨质疏松症患者的生命质量。

Methods:The treatment of 18 cases with bone cysts was reviewed,which there were treated from January 2004 to February 2005. There were12 males and 6 females with an average age of 13 years?old. The bone cysts were located in the proximal humerus（n=9）,proximal femur（n=4）,proximal tibia（n=1）,distal tibia（n=1）,proximal ulna（n=1）,distal ulna（n=1）,and distal radius（n=1）.Under fluoroscopy, two fine bone marrow biopsy needls pierced the bone cysts from the top and the bottom of the cyst respectively.The intracystic fluid was drawn out,the cyst cavity was irrigated and then the tissue engineering complexation of autologous red bone marrow and methylprednisolone with sodium hyaluronate was injected in percutaneously.

2004.1～2005.2月，对18例骨囊肿患者（男12例，女6例，平均年龄13岁；其中肱骨近端9例，股骨近端4例，胫骨近端1例、远端1例，尺骨近端1、远端1例，桡骨远端1例）以玻璃酸钠为载体抽取自体红骨髓加入甲基强的松龙，在X线透视下，将2根骨穿针经皮分别自囊腔顶部和底部刺入骨囊肿内，抽去囊液，冲洗囊腔后注入复合物。

Micronucleus test results exhibited that significant differences in micronuclear rates were determined between 0.4 mL bone cement and 0.4 mL microsphere-coated bone cement groups and negative control group, but no significant difference was detected among other groups. This revealed that this microsphere-coated bone cement leaching liquor did not show significant cell heredity toxic effects. Nevertheless, microsphere-coated bone cement in the high concentration and high dosage groups exhibited low toxic effects, mainly showing increased hemolysis rate and micronuclear rate. Thus, it was necessary to control the dosage and concentration of microsphere-coated bone cement.

微核实验结果显示除0.4 mL骨水泥组和0.4 mL微球骨水泥组的微核率与阴性对照组差异有显著性意义，其余各组差异无显著性意义，说明该微球骨水泥的浸提液无明显细胞遗传毒性作用，但是高浓度和高剂量组的微球骨水泥仍有较低的毒性作用，主要表现为溶血率和微核率的提高，因此在应用时要适当控制微球骨水泥的剂量和浓度。

BACKGROUND: Bone morphogenic protein 2 is one of the most important growth factors in the healing of bone fracture. The main function is to promote the undifferentiated mesenchymal cells and bone cells to recruitment and differentiate. It is the promoter of bone formation. The BMP-2 gene is an ideal gene that can be used to repair the bone.

背景：骨形成蛋白2是骨基质中最重要骨生长因子，主要生物学作用是促进未分化的间充质细胞和骨系细胞的募集和分化，是骨生成的启动因子，可以作为骨修复基因治疗的理想目的基因。

The BG100 series osteoporosis treatment meter use curative effect is remarkable, not can only improve the skeleton quality, the prevention bone fracture, to cut the bone fracture formation rate, the acceleration bone fracture cicatrization; May also use in treating the soft tissue damage, osteoarthropathy, the bone not to link, the bone fracture difficultly to heal and so on, and can promote young people's growth.

BG100系列骨质疏松治疗仪使用疗效显著，不但能改善骨骼质量、预防骨折、降低骨折发生率、加速骨折愈合；还可以用于治疗软组织损伤、骨关节病、骨不连、骨折难愈合等，并能促进青少年的生长发育。

The microstructure of the sintered bone was observed by scanning electron microscope and mercury porosimeter. Results showed that the sintered bone possess the three dimensional space structure composed of macropores and micropores. The diameter of macropore was 50-400 μm and the diameter of micropore was about 1 μm. Results suggest the sintered bone of β-TCP remains the porous structure of natural cancellous bone which is benefit to growing of new bone.

结果显示β-磷酸三钙煅烧骨具有大孔结构和微孔结构相结合的三维空间结构，大孔孔径为50~400 μm，微孔孔径为1 μm左右，提示β-磷酸三钙煅烧骨保留了天然松质骨的多孔状结构，有利于新生骨组织的长入。

We show using in vitro and in vivo models that active TGF-beta1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to the bone resorptive sites and that this process is mediated through a SMAD signaling pathway.

我们利用体外和体内模型，发现在骨吸收过程中释放的有活性的TGF-β1通过诱导骨髓基质细胞的迁移至骨重吸收位置来调节骨形成，这一过程通过SMAD信号途径调节。

Obvious cartilage and island-distributed immature bone formation in implants of the experiment side were observed at 2 weeks after operation, and massive mature bone observed at 4 weeks. Newly formed bone had fused and formed mature lamellar bone and trabecularism. No bone formation was observed in the control side of the mice.

实验侧术后2周出现大量软骨组织和呈岛状散在分布的骨组织，术后4周可见大量成骨组织，新生骨相互融合生长并形成较为成熟的板层骨和骨小梁结构；对照侧未见骨组织形成。

Transiliac bone biopsy showed highly increased bone mass (+63% versus age- and sex-matched controls), a decrease in bone remodeling without evidence of active osteoblasts, and a severe decrease in the dynamic parameters of bone formation (mineralizing surfaces,-90% and bone formation rate,-93% versus age- and sex-matched controls).

经髂骨的活检示骨量显著增加（与年龄和性别匹配的对照者相比增加了63％），骨重建降低且没有发现破骨细胞活化的证据（与年龄和性别匹配的对照者相比：矿化面-90%，骨形成率-90%）。

When this condition occurs, inbound replication with the source partner is stopped on the destination domain controller and event ID 2042 is logged in the Directory Services event log.

计算机密码学是研究计算机信息加密、解密及其变换的科学，是数学和计算机的交义学科，也是一门新兴的学科。

Instructions: click on the thumbnails to see a larger image, then use the left-right arrow keys to scroll through the slideshow.

使用说明：滑鼠点在小图上即可放大观赏。开启后键盘左右键可用来换照片。