基因

基本解释 (translations)

gene  ·  genetically  ·  homogeneously  ·  Gene  ·  genes

词组短语

germ plasm · efficient cause · Mendelian factor · Mendelian unit

与基因相关的网络例句 [注：此内容来源于网络，仅供参考]

DYS522 sites examine proptosis 5 discrimination power with personal allele,allelomorph to 0.6495,the excluding probability of paternit is;DYS508 sites examine proptosis 6 discrimination power with personal allele, allelomorph to 0.7006,the excluding probability of paternit is;DYS632 sites examine proptosis 3 discrimination power with personal allele,allelomorph to 0.5224,the excluding probability of paternit is;DYS556 sites examine proptosis 6 discrimination power with personal allele,allelomorph to 0.7454,the excluding probability of paternit is.

DYS522基因座共检出5个等位基因9～13，频率分布范围0.0447-0.5075，11频率最高(0.5075)，DP值为0.6495；DYS508基因座共检出6个等位基因8～13，等位基因频率分布范围0.0149～0.4030，11频率最高(0.4030)，DP值为0.7006；DYS632基因座共检出3个等位基因10～12，等位基因频率分布范围0.0149～0.4926.11频率最高(0.4926)，DP值为0.5224；DYS556基因座共检出6个等位基因9～14。等位基因频率分布范围0.0149～0.3433，9频率最高(0.3433)，DP值为0.7454。

Along with the fluconazole solution density rise,the experimental two kind of strain various glucose density is higher,showe d the glucose consumption are less,takes the logarithmof the medicine de nsity,discovered the logarithm the medicine density and each glucose den sity presents the linear relations;Carries on the analysis comparison to under the fluconazole function two kind of strain linear relations,disc overed the relations of the two strains has the nonuniformity.3 Compare the fluconazole induction reaiatance SC5314 strain and sens itive strain compares,its difference gene expression mainly concentrates in:The code proteinase body and the protein hydroltyic enzyme gene,in the code sugar fat metabolism process is connected the protein gene,the cell cycle correlation gene,the duplication and the translation adjustme nt correlation gene,the stress response correlation gene,the line plast ochondria correlation gene,the cell wall function related gene.4 Candida albicans SC5314 induction resiatance strain was processed b y Xianglian solution,its expression change gene mainly is:Code stress re sponse family protein gene,biomembrane relevant gene,a code proteinase body gene race,code cell cycle related protein gene,duplication and tra nslation adjustment related protein gene.5 The clinical reaiatance strain Candida albicans was processed by Xi anglian solution,its expression change gene mainly is:Codes the hot sho ck protein gene,the serine/threonine protein activating enzyme gene,the proteinase body family gene,the regulation copies and translates the ge ne.

随着氟康唑药液的浓度上升，试验的两种菌株各孔葡萄糖浓度越高，说明葡萄糖消耗越少，经过药物浓度取对数后进行分析，发现取对数后的药物浓度和每孔中葡萄糖浓度者呈现线性关系；对氟康唑作用下的两种菌株的线性关系进行分析比较，发现对两种菌株作用具有不一致性。3氟康唑诱导的耐药SC5314菌株与诱导前的敏感株相比，其差异基因表达主要集中在：编码蛋白酶体及蛋白水解酶的基因，编码糖脂代谢过程中相关蛋白的基因，细胞周期相关基因，转录及翻译调节相关基因，应激反应相关基因，线粒体相关基因，细胞壁功能相关基因。4白念珠菌SC5314诱导耐药株经香莲外洗液作用后，其表达变化的基因主要是：编码应激反应家族蛋白的基因，生物膜相关性基因，编码蛋白酶体基因一族，编码细胞周期相关蛋白基因，转录及翻译调节的相关蛋白基因。5白念珠菌临床耐药菌株经香莲外洗液作用后，其表达变化的基因主要是：编码热休克蛋白基因，丝氨酸/苏氨酸蛋白激酶基因，蛋白酶体家族基因，调控转录及翻译基因。

In order to reduce calculation error, the frequency distribution of average values is used to compute the mixed distribution's digital features of each component distribution, thereinto, the number of the component distribution is determined by AIC, choose the number that meets the minimum value of AIC as the component number of mixed distribution, and the other parameters are estimated by EM algorithm; Secondly, because each component distribution is corresponding to a kind of major gene genotype, according to the values of the average and variance of the each component distribution, we can use the limit error of the normal distribution to plot each individual into the correspondent component distribution, namely into correspondent major gene genotype. Then we regard each major gene genotype as a treatment level of one-way analysis of variances, and the one-way multivariate analysis of variance is carried out to calculate the covariance matrix of major gene effect, covariance matrix of polygene effect, covariance matrix of environment effect and so on; At last, combining the weights of the each component distribution of mixed distribution, we can calculate the variance of major gene effect, the variance of polygene effect, environmental variance and the genetic gain of the quantitative trait.

为减小计算误差，本研究采用均值的频数分布来计算各成分分布的数字特征，其中成分分布个数根据AIC准则，选择使AIC值达到最小的成分分布个数作为混合分布的成分分布数，分布中其它参数的确定利用EM算法来估计；其次，每个成分分布对应一种主基因基因型，根据各个成分分布的均值和方差，利用正态分布的极限误差将每个个体划分到相应的成分分布中，即相应的主基因基因型中，将每种主基因型作为单因素方差分析的一个处理水平，对其进行单因素的多元方差分析，分别计算主基因效应协方差阵、多基因效应协方差阵、环境协方差阵等参数；最后结合混合分布中各成分分布的权重即各主基因基因型的分离比例，计算主基因效应方差，多基因效应方差和环境方差，以及遗传力等参数，进而计算该数量性状的遗传进展。

Objective To investigate the expression of 基因 Pgp protein and apoptosis and its significance in bladder cancers.

摘 要］目的：研究膀胱癌P53阳性、基因、MDM2意义凋亡的表达。

In our study, 3 genotypies have been respectively demonstrated in UL139 and UL149 for the first time, and the corelations between certain genotypical structure and certain diseases were also proposed; The existence of the 3 genotypes of UL144 was foremost verified in isolates from congenital infants; Furthermore, the UL140, UL141 and UL145 genes were observed to be greatly discrepant to those had been described previously: comparing with Toledo, 231 nt are inserted in UL140, 2 more ORFs are obtained in UL141, and the UL145 ORF moves upstream by 90 nt. Except UL144, the sequences of 18 else genes in clinical isolates were submitted for the first time, and 479 sequences were assigned by GeneBank in total. Relevantly, 9 papers were published.

我们在学术界首次证实了HCMV UL139、UL149两个基因在临床分离株中分别存在三种基因型，发现了其中某个基因型的基因结构与特定来源的分离株存在一定的对应关系；首次在先天感染分离株中验证了UL144三种基因型的存在；首次证实了UL140、UL141和UL145等基因与原先认识的基因结构不同，其中UL140基因较Toledo株增加了231个碱基、UL141产生2个新的基因编码区、UL145 ORF较Toledo株前移90个碱基；首次或最先提交了除UL144基因外其余18个基因的临床分离株序列，本项目组共有479个HCMV相关基因序列被GenBank收录；发表研究论文9篇。

We initiated a genetic screen for Drosophila olfactory genes by means of SG18.1-Gal4/UAS system: The result validates our screen as an rapid, effective approach for recovering genes controlling glomerular map patterning; From a misexpression screen of 1,515 P{GS} lines, we identified 23 genes that, when forcibly expressed in the olfactory receptor neurons, disrupted the stereotyped anatomy of the Drosophila antennal lobes; These genes, which have not been shown previously to control olfactory map development, encode novel proteins as well as proteins with known roles in axonal outgrowth and cytoskeletal remodeling.

本文首次利用SG18.1-Gal4／UAS基因筛选系统对果蝇嗅觉基因进行了筛选和鉴定：结果表明，所采用的方法可以快速、有效地分离到果蝇嗅觉相关基因；从1515株果蝇P{GS}品系分离到86株突变体，其中40株有明显表型，从中鉴定了23个基因，这些基因在ORN强迫表达时可以损坏果蝇嗅叶的固有结构；在筛选中发现的一些调节嗅觉图谱发育的基因可以编码新蛋白或编码参与轴突生长和细胞骨架重塑的蛋白；为了便于研究，根据基因的功能和所编码蛋白的特点，我们对分离到的基因进行了分类，即参与轴突引导和突触产生、调节转录、调节细胞骨架和功能未确定或未知的基因；并通过对嗅觉感觉器的检测发现，除了调节转录的基因外，其他基因对触觉器的数量和分布影响不明显。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

This study investigated gene polymorphism of β_1-AR, CY2PD6, ACE and of BDKRB2 in the population of Hunan mid-region by PCR and PCR-RFLP method. The results showed that the frequencies of Ser49Ser and Arg389Arg genotype of β_1-AR gene were respectively 68.7% and 55.3%. And the allele frequencies of 49Ser and 49Gly were 83.9% and 16.1%, moreover 76.1% for 389Arg and 23.9% for 389Gly.

本研究应用PCR、PCR-RFLP方法首次对湖南中部地区403例原发性高血压患者的β_1-AR基因、CY2PD6基因、ACE和BDKRB2基因多态性的调查，结果显示：β_1-AR基因型Ser49Ser、Arg389Arg分别占68.7％、55.3％，49Ser和49Gly等位基因频率分别为83.9％、16.1％，389Arg和389Gly等位基因频率分别为76.1％、23.9％；CYP2D6等位基因频率由高到低依次为~*10、~*1、~*2、~*5，CYP2D6~*10~*10基因型频率最高，占47.4％；ACEI和D等位基因频率分别为55.8％、44.2％，基因型频率分别为Ⅱ型33.5％、ID型44.7％、DD型21.8％；BDKRB2-58T/C等位基因频率C、T分别为52.6％、47.4％，基因型频率分别为CC型24.8％、CT型55.6％、TT型19.6％。

Methods Apoptosis Index was assessed with TUNEL technique,and immunohistochemical stainings of 基因 and Pgp were performed in 83 cases of the carcinomas and 11 "normal" bladder mncosa.

采用免疫组织化学方法及TUNEL法检测11例&正常膀胱黏膜&和83例膀胱移行P53癌中基因、MDM2意义的凋亡及P53阳性指数。

The chip used contains 4097 genes covering oncogenes and tumor suppressor genes, the genes related to ion channels, cell cycle proteins, outer force reaction proteins, cell skeleton and movement, and apoptosis, the genes associated with DNA synthesis, repair and recombination, the genes related to DNA combining and transcription, the genes encoding cell receptors, the genes related to signaling, the genes associated with immune response, metabolism, protein synthesis, development and others.

实验所用的芯片含有4097个基因，包括原癌基因和抑癌基因、离子通道和运输蛋白基因、细胞周期蛋白基因、外压反应蛋白基因、细胞骨架蛋白和运动相关基因、细胞凋亡相关蛋白基因、DNA合成和修复和重组相关蛋白基因、DNA结合和转录和转录因子基因、细胞受体基因、免疫相关基因、细胞信号传导蛋白基因、代谢相关蛋白基因、蛋白质翻译和合成相关基因、发育相关基因、及其它基因。

与基因相关的网络解释 [注：此内容来源于网络，仅供参考]

Multiple allele：复等位基因

造成基因多态性的原因:1复等位基因(multiple allele)位于一对同源染色体上对应位置的一对基因称为等位基因(allele). 由于群体中的突变,同一座位的基因系列称为复等位基因. 某些复合体基因的每一座位都存在为数众多的复等位基因,

gene transfer：基因转移

2.1O 基因治疗 基因转移(gene transfer)和基因转染(gene transfection)技术是近年来分子生物学迅速发展的重要标志,也是临床基因治疗的主要手段. 近几年,OA的基因治疗得到迅速发展,但在基因治疗运用于临床之前,必须解决以下问题:①目的基因的选择;

genotype frequency：基因型频率

40基因频率(gene frequency)指特定位点上一个等位基因数目占该位点上全部等位基因总树的比率,也可以说是该等位基因在群体中出现的频率. 41基因型频率(genotype frequency) 群体内特定基因型数目占该基因位点全部基因型的数目总合的比率叫做基因型频率.

locus：基因座

等位基因(Allele): 在染色体上占据相同位置的两个不同的基因 基因座(Locus): 基因在染色体所处的位置. 特定的基因在染色体上都有其特定的座位. 每个基因座上,有 两个等位基因. 显性基因(Dominant Gene): 在杂合状态中,

epistatic gene：上位基因

一对等位基因受到另一对等位基因的制约,并随着后者不同前者的表型有所差异,后者即为上位基因(epistatic gene). 这一现象称为上位效应(epistasis). 起遮盖作用的基因如果是显性基因,称为上位显性基因. 这种基因互作称为显性上位作用(dominant epistasis).

genomic library：基因文库

的筛选和鉴定 目的基因(target DNA)的制备 目的基因 目的基因(外源基因) 目的基因(外源基因) 制备基因组DNA 制备基因组 - 基因文库(genomic library)-存在于转化细菌 基因文库 存在于转化细菌 克隆载体携带的所有基因组DNA的集合中,

promotor：启动基因

一个操纵子又包含3种基因,即结构基因(structure gene)、操纵基因(opera tor)和启动基因(promotor). 结构基因是通过转录和翻译过程来执行多肽(酶及结构蛋白)合 成的,操纵基因是与结构基因紧密连锁在一起的,是阻遏蛋白的附着部位,

multiple alleles：复等位基因

HLA的多态性主要是由于复等位基因和共显性所致: (1)复等位基因(multiple alleles),位于一对同源染色体上对应位置的一对基因叫等位基因. 由于群体的突变,同一基因座的基因系列称为复等位基因,对某一个体来说一个基因座只有一对等位基因,

gene mutation：<基因词汇Gene> 基因突变

gene locus <基因词汇Gene> 基因位点 | gene mutation <基因词汇Gene> 基因突变 | gene regulation <基因词汇Gene> 基因调节

oncogene：癌基因,原癌基因

原癌基因 原癌基因(oncogene)是细胞内与细胞增殖相关的基因,是维持机体正常生命活动所必须的,在进化上高等保守. 当原癌基因的结构或调控区发生变异,基因产物增多或活性增强时,使细胞过度增殖,从而形成肿瘤. 原癌基因的产物主要包括(表13-2,