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The total flavonoids content of peanut hulls of different sources were evidently different,those peanut hulls contained more total flavonoids from Shandong province,higher maturity and raw. This suggested that attention should be paid to the choice of peanut hulls as medicine materials. 3.The optimized extraction technology conditions considering the two indices of total flavonoids andβ-sitosterol were: the peanut hulls were extracted by 95% acohole 6 times of the hulls weight refluxing for 2 hours first,and extracted by 70% acohole 4 times of the hulls weight refluxing for 2 hours at the temperature below 80℃successionally,then the concentrate was dried vacuumizedly with the additament of starch 2% of the concentrate weight after the extracts were fitrated,united and concentrated. 4.The dried extract powder possessed high hygroscopy and low fluidity,but the weight variation of capsule contents could comply with the requirement of CP if it was mixed with dextrin and granulated by sieving 40 meshes using 95% ethanol as the wetting agent,and filled into capsules after dried below 60℃.The critical relative humidity of the granules was about 63%.
不同来源的花生壳总黄酮含量有较大差异，山东产区、成熟度高的及未经炒制的花生壳总黄酮含量较高，提示作为药材时应注意选择； 3、兼顾总黄酮及β-谷甾醇的最佳提取工艺为：先以95%乙醇6倍量加热回流提取2小时，再以70%乙醇4倍量80℃以下回流提取2小时，提取液过滤、合并、浓缩，加2%淀粉60℃以下减压干燥； 4、浸膏粉吸湿性大，流动性差，但加糊精并以95%乙醇为润湿剂、过40目筛制粒，60℃以下烘干后填充胶囊，可保证装量差异符合要求；颗粒临界相对湿度约为63%。
The 3rd it is right advertisement suffers numerous dog successionally in the behavior lack that crosses agency environment to fall measure research
The numerical tests of IEEE standard example have shown that the proposed method has excellent convergence characteristics and more better robust, successionally analyzed and explained the results of algorithm.
TiO2 films with various thicknesses have are deposited on the ZrO2 buffer layer and treated at 900℃ for 1h successionally.
In conclusion , ERK and telomerase serve a function to some extent in drug resistance of leukemia and ovariancarcinoma cells. The inhibition of ERK signal transduction pathways led to reduction of phosphorylated ERK1 and ERK2protein expression level , and successionally down2regulated the telomerase activity.
通过阻抑ERK通路，降低磷酸化ERK1/ 2蛋白表达水平，进而下调端粒酶活性，可以达到增强白血病和卵巢癌耐药细胞对HRT 或DDP 敏感性的目的。
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